A5007456580- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Complementary and Alternative Medicine Studies
- Glycosylation and Glycoproteins Research
- High Altitude and Hypoxia
- Digestive system and related health
- Inflammatory Biomarkers in Disease Prognosis
- Protease and Inhibitor Mechanisms
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Dermatology and Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Pulmonary Hypertension Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- AI in cancer detection
- Immune Cell Function and Interaction
- Immune cells in cancer
- Peptidase Inhibition and Analysis
University of Oulu
2022-2025
Oulu University Hospital
2024-2025
Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not described sufficient detail introduce tumor into clinical use. To study the potential of as a indicator criteria for 3 were defined: average percentage method (tumor whole tumor), hotspot single hotspot), and linear (the diameter largest necrotic focus). Cox regression models used calculate cancer-specific mortality hazard ratios (HRs) categories 2 cancer...
<title>Abstract</title> Colorectal cancer, the second most fatal malignancy globally, burdens public healthcare systems. AI-assisted cancer diagnostics could enable significant cost savings. This study presents a multi-scale ensemble model for DNA mismatch repair deficiency (dMMR) detection from Whole Slide Images (WSIs). dMMR is clinically important feature, traditionally identified through labor- and time-intensive analysis. The prediction capability of non-tumorous regions was also...
Abstract Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is a multifaceted, cytokine-like bioactive molecule whose levels are elevated in wide range inflammatory diseases and associated with prognosis. Additionally, TIMP1 may play role driving systemic inflammation. immunohistochemistry serum concentrations were analyzed cohort 776 colorectal cancer patients. histoscore by cell type (tumor cell, other) was quantified using digital image analysis. Serum evaluated for correlations tumor...
Abstract Micropapillary colorectal adenocarcinoma is a morphologic subtype of cancer (CRC) with insufficiently characterized prognostic significance and biological features. We analyzed the histopathological, immunological, features micropapillary in two independent CRC cohorts ( N = 1,876). found that adenocarcinomas accounted for 4.9% 6.4% CRCs cohorts. A growth pattern was associated advanced stage lymphovascular invasion p < 0.001), but also shorter overall survival these factors...
Abstract Background The production of extracellular mucus and expression mucins are commonly aberrant in colorectal cancer, yet their roles tumour progression remain unclear. Methods To investigate the potential influence on immune response prognosis, we analysed mucinous differentiation (non-mucinous, 0%; component, 1–50%; mucinous, >50%) its associations with cell densities (determined three multiplex immunohistochemistry assays or conventional immunohistochemistry) survival 1049 cancer...
Abstract Background Caudal-type homeobox 2 (CDX2) and special AT-rich sequence-binding protein (SATB2) are transcription factors playing important roles in intestinal homeostasis participating the regulation of inflammation. In colorectal cancer (CRC), reduced expression levels CDX2 SATB2 have been associated with poor differentiation worse survival. However, their prognostic significance still needs further clarification, associations between immune cell infiltration into CRC...
Abstract Background SARIFA (Stroma AReactive Invasion Front Areas), defined as the direct contact between a tumour cell cluster and adipose cells at invasion margin, has been proposed prognostic marker in gastrointestinal cancers. We hypothesized that is associated with an immunosuppressive microenvironment. Methods status was evaluated two large colorectal cancer cohorts ( N = 1876). Survival analyses were performed using multivariable Cox regression. Immune densities analysed utilizing...
Abstract Hypoxia plays an important regulatory role in the vasculature to adjust blood flow meet metabolic requirements. At level of gene transcription, responses are mediated by hypoxia-inducible factor (HIF) stability which is controlled HIF prolyl 4-hydroxylase-2 (PHD2). In lungs hypoxia results vasoconstriction, however, pathophysiological relevance PHD2 major arterial cell types; endothelial cells (ECs) and smooth muscle (aSMCs) adult incompletely characterized. Here, we investigated...
Gut bacterial alterations have been previously linked to several non-communicable diseases in adults, while the association of mycobiome is not well understood these diseases, especially infants and children. Few studies conducted on between gut We investigated composition using 194 faecal samples collected at birth, 6 months after 18 birth relation atopic dermatitis (AD) overweight diagnoses age or 36 months. The exhibited distinct patterns, with Truncatella prevalent meconium both...