A5011354806- Gut microbiota and health
- Urinary Tract Infections Management
- Dermatology and Skin Diseases
- Metabolism and Genetic Disorders
- Infant Health and Development
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Streptococcal Infections and Treatments
- Lung Cancer Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Blood disorders and treatments
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Reproductive tract infections research
- Immune Response and Inflammation
- Adolescent and Pediatric Healthcare
- Pediatric health and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Pediatric Urology and Nephrology Studies
University of Oulu
2019-2024
Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of long-term effects on gut microbiota and subsequent health children limited. Here, we compared impacts perinatal exposure later courses microbiota.This was a prospective, controlled cohort study among 100 vaginally delivered infants with different exposures: control (27), IAP postnatal antibiotics (24), (22). At 1 year age, performed next-generation sequencing bacterial 16S ribosomal RNA gene fecal samples.Exposure...
Summary Background Several reports have revealed that the first‐pass meconium hosts a diverse microbiome, but its clinical significance is not known. Objective We designed prospective population‐based cohort study to evaluate whether microbiome predicts subsequent growth in children. Methods The comprised 212 consecutive newborns with sample and follow‐up at 1 year of age. Trained nurses measured children for weight length using standardized techniques. used next‐generation sequencing...
Mother vaginal microbes contribute to microbiome of vaginally delivered neonates. Child can be associated with autoimmune diseases, such as type 1 diabetes (T1D). We collected DNA samples from 25 mothers a child diagnosed T1D and 24 control who had healthy analyzed bacteriome mycobiome the samples. The total was extracted, ribosomal regions (16S for bacteria, ITS2 fungi) were amplified, followed by next-generation sequencing machine learning. found that alpha-diversity increased (P < 0.002),...
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most studies have used the sequencing of bacterial 16S marker gene but not reported metabolic function microbiome, which may mediate biological effects on host. Here, we PICRUSt2 bioinformatics tool to predict functional profiles based two child cohorts. Both Caesarean section markedly influenced at age 1 year. In machine learning analysis, fatty acid, phospholipid, biotin biosynthesis were most...
Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The of the first-pass meconium, which forms before birth, represents first easily available for research and little known about any relationship disease development.We investigated whether bacterial meconium development 4 years age.Prospective birth study. Bacterial was analysed using 16S rRNA gene amplicon sequencing. Atopic were evaluated via online survey or telephone to...
Background: Probiotic lactobacilli have been ineffective in preventing acute otitis media. In contrast to lactobacilli, alpha-hemolytic streptococci belong the core microbiome of nasopharynx. Methods: We investigated effects Streptococcus salivarius K12 probiotic on saliva and nasopharyngeal 121 children attending daycare. Children were randomly allocated receive oral product for 1 month or no treatment. obtained samples at study entry, 2 months. The next-generation sequencing bacterial 16S...
ABSTRACT Combining and comparing microbiome data from distinct infant cohorts has been challenging because such are inherently multidimensional complex. Here, we used an ensemble of machine-learning (ML) models studied 16S rRNA amplicon sequencing 4,099 gut samples representing 12 prospectively collected cohorts. We chose the childbirth delivery mode as a starting point for analysis it previously associated with alterations in infants. In cross-study models, Bacteroides was most important...
Gut bacterial alterations have been previously linked to several non-communicable diseases in adults, while the association of mycobiome is not well understood these diseases, especially infants and children. Few studies conducted on between gut We investigated composition using 194 faecal samples collected at birth, 6 months after 18 birth relation atopic dermatitis (AD) overweight diagnoses age or 36 months. The exhibited distinct patterns, with Truncatella prevalent meconium both...
Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA) is the most common periodic fever in children with unknown etiology, effectively treated tonsillectomy. Earlier we have shown that tonsil microbiome different patients PFAPA as compared to controls. Recently, fungal microbiome, mycobiome, has been linked pathogenesis of inflammatory diseases. We now investigated role mycobiome tonsils PFAPA. Random forest classification, a machine learning approach, was used for...