A5079937630- Pancreatic function and diabetes
- IL-33, ST2, and ILC Pathways
- Adipose Tissue and Metabolism
- Cutaneous lymphoproliferative disorders research
- Adipokines, Inflammation, and Metabolic Diseases
- Skin and Cellular Biology Research
Leipzig University
2023-2024
White adipose tissue (WAT) fibrosis, characterized by an excess of extracellular (ECM) matrix components, is strongly associated with WAT inflammation and dysfunction due to obesity. Interleukin (IL)-13 IL-4 were recently identified as critical mediators in the pathogenesis fibrotic diseases. However, their role fibrosis still ill-defined. We therefore established ex vivo organotypic culture system demonstrated upregulation fibrosis-related genes increase α-smooth muscle actin (αSMA)...
Obesity is concurrent with immunological dysregulation, resulting in chronic low-grade inflammation and cellular dysfunction. In pancreatic islets, this loss of function has been correlated mature β-cells dedifferentiating into a precursor-like state through constant exposure to inflammatory stressors. As adipocytes likewise have the capability dedifferentiate vitro vivo, we wanted analyze change relation adipose tissue (AT) macrophage (ATM) activity. Using our organotypic AT explant culture...