A5058194567- Neurobiology and Insect Physiology Research
- Innovations in Medical Education
- Protein Structure and Dynamics
- Empathy and Medical Education
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Anatomy and Medical Technology
- Clinical Reasoning and Diagnostic Skills
- Plant biochemistry and biosynthesis
- Receptor Mechanisms and Signaling
- Healthcare professionals’ stress and burnout
- Porphyrin and Phthalocyanine Chemistry
- Diversity and Career in Medicine
- Synthesis and Catalytic Reactions
- COVID-19 and Mental Health
- interferon and immune responses
- Music Therapy and Health
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Synthesis of β-Lactam Compounds
- Surgical Simulation and Training
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Simulation-Based Education in Healthcare
- Crystallization and Solubility Studies
Helmholtz-Zentrum Berlin für Materialien und Energie
2024
Humboldt-Universität zu Berlin
2024
Texas Tech University
2024
Texas Tech University Health Sciences Center
2024
Kansas City University
2019-2022
Integra (United States)
2021
Van Andel Institute
2008-2010
Rocky Vista University
2010
Parker Hannifin (United States)
2010
University of Colorado Denver
2006-2008
The chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and II) make up the most conserved subfamily of nuclear receptors that play key roles in angiogenesis, neuronal development, organogenesis, cell fate determination, metabolic homeostasis. Although biological functions COUP-TFs have been studied extensively, little is known their structural features or aspects ligand regulation. Here we report ligand-free 1.48 A crystal structure human COUP-TFII ligand-binding domain....
Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear that play important roles in spermatogenesis, lipid lipoprotein regulation, the development central nervous system. Currently, little is known about structural features ligand regulation these receptors. Here we report crystal structure ligand-free TR4 binding domain, which reveals an autorepressed conformation. The pocket filled by C-terminal half helix 10, cofactor site occupied AF-2 helix, thus preventing...
LUSH is an odorant binding protein expressed in the olfactory organs of Drosophila melanogaster that required for detection alcohol adult flies. Here we demonstrate that, absence ligand, vitro exists a partial molten globule state. The presence short-chain n-alcohols at pharmacologically relevant concentrations less than 50 mM shifts conformational equilibrium to more compact state exhibits reduced fluorescent dye 1-anilino-8-naphthalenesulfonic acid. Equilibrium unfolding studies...
Abstract Gross anatomy laboratories frequently utilize dissection or prosection formats within medical curricula. Practical examination scores are consistent across the formats, yet these examinations assessed larger anatomical structures. In contrast, a single report noted improved when was used in hand and foot regions, areas that more difficult to dissect. The incorporation of prosected donors “Head Neck” provided an opportunity further characterize impact structurally complex area....
Abstract Mononuclear inorganic diradical species are scarce. Here, we confirm, via X‐ray absorption spectroscopy in the gas phase combined with computational studies, oxygen‐centered character of tetraoxidorhenium(VII) cation. A dioxido‐superoxido isomer, close energy to diradical, is also found, where rhenium appears its rare oxidation state +6. Addition one or two hydrogen atoms [Re,O 4 ] + forms hydroxido ligands, and strongly disfavors isomers any oxygen‐oxygen bond. This adds...
INTRODUCTION/OBJECTIVE: Kansas City University has historically used student-led dissections for anatomy education in the first year medical curriculum. In academic (AY) 2019-20, prosected cadaver specimens were incorporated ‘head and neck’ component of Neuroendocrine (NE) course. Literature addressing use cadavers yields identical student outcomes when assessing larger structures like extremities as compared to dissections, however, a single report indicates that areas with exceedingly...