<b>Objective:</b> To assess the hazards at an early phase of growing epidemic deaths from tobacco in China. <b>Design:</b> Smoking habits before 1980&nbsp;(obtained family or other informants) 0.7&nbsp;million adults who had died neoplastic, respiratory, vascular causes were compared with those a reference group 0.2&nbsp;million causes. <b>Setting:</b> 24 urban and 74&nbsp;rural areas <b>Subjects:</b> One million people during 1986-8 whose families could be interviewed. <b>Main outcome...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConsumption and fate of aflatoxin B1 by lactating cowsCarl E. Polan, Johnnie R. Hayes, T. Colin. CampbellCite this: J. Agric. Food Chem. 1974, 22, 4, 635–638Publication Date (Print):July 1, 1974Publication History Published online1 May 2002Published inissue 1 July 1974https://pubs.acs.org/doi/10.1021/jf60194a027https://doi.org/10.1021/jf60194a027research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations50LEARN...

Background: Hypertension-related diseases are the leading causes of morbidity and mortality in industrially developed societies. Surprisingly, 68% all attributed to high blood pressure (BP) occurs with systolic BP between 120 140 mm Hg diastolic below 90 Hg. Dietary lifestyle modifications effective treatment borderline hypertension. One such intervention is use medically supervised water-only fasting as a safe means normalizing initiating health-promoting behavioral changes. Methods:...

Abstract A case‐control study investigating the association between plasma lipids and breast cancer was conducted among women aged 30–80 in Buffalo, NY. All eligible from a large clinic two area physicians' offices were requested to participate over one‐year period. Subjects completed health questionnaire donated fasting blood sample prior diagnostic biopsies. The 83 found have (cases) had significantly higher triglyceride values than did 113 not (controls). Lower β‐carotene associated with...

This study investigates prior reports of high neuropsychological symptom validity test (SVT) failure rates in post-deployed Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) active and veteran military personnel, using a large, multi-site sample (N = 214) drawn from three levels the Department Defense/Department Veterans Affairs (VA) Polytrauma System Care. The rate its relationship to research versus dual research/clinical context evaluation were examined, addition secondary...

Abstract The effects of β‐carotene, canthaxanthin, and extracts tomato paste (containing lycopene) orange juice cryptoxanthin) on aflatoxin B1 (AFB1)‐induced mutagenesis in S. typhimurium TA 100 98 were investigated. Inhibition was studied during following completion AFB, metabolism (i.e., after the addition menadione), thereby permitting separate examination metabolic activation phenotypic expression phases. Each experimental carotenoid, except lycopene, inhibited AFB1‐induced both tester...

Abstract The effects of sequential alterations in the feeding two levels dietary protein (5% and 20% casein) on postinitiation development aflatoxin B1‐ (AFB1) induced γ‐glutamyl transpeptidase‐positive (GGT+) preneoplastic foci were examined. Weanling male Fischer 344 rats fed AIN‐76A diet (20% protein) administered 10 intragastric doses AFB1 (1 dose/day during 14‐day dosing period excluding weekends) at 250 ng/kg body wt (initiation). After tissue clearance, randomly assigned to treatment...

Previous studies in this laboratory with young Fischer 344 male rats have shown that the post-initiation development of aflatoxin B1 (ATB1)-induced gamma-glutamyltranspeptidase positive (GGT+) hepatic foci was markedly inhibited by low protein feeding, even though energy intake greater. This dietary effect, however, did not necessarily apply to tumor development. Thus, present investigation undertaken examine effect upon tumors and, so doing, determine correlation Following AFB1 dosing (15...

The effect of the quality dietary protein on post-initiation development aflatoxin B1-initiated putatively preneoplastic foci in Fischer 344 rat liver was compared with quantity protein. Feeding wheat gluten, a low-quality protein, during period (between end B1 dosing and death rats) inhibited γ-glutamyltransferase-positive when that animals fed high-quality (casein) diets same period. Lysine supplementation gluten postinitiation enhanced response to level comparable These results suggest...

Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure pharmacologically active compounds may be a determinant cancer risk.

Professional interest in the association of diet and nutrition with cancer first appeared early 1800s, if not before. Yet, progress understanding this over past two centuries has been exceedingly slow confusing. Without addressing confusion, using information to prevent even treat cancer, will remain uncertain. To better understand issue, present paper is explore history relationship prior a 1982 National Academy Sciences (NAS) report on Diet, Nutrition Cancer. This was milestone because it...

The development of aflatoxin B1-induced hepatic preneoplastic lesions was significantly modified by varying the level dietary casein fed to animals during post-dosing period. Using gamma-glutamyl transferase staining identify areas cellular alteration, we observed that a 5% diet showed 75% reduction in lesion as compared 20% diet. Increasing from 40% produced no further increase response. results study, showing an inhibition after dosing, suggest low inhibits promotional phase ultimate neoplastic