A5072232542- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Biomarkers in Disease Mechanisms
- Heat shock proteins research
- Inflammatory Bowel Disease
- Endoplasmic Reticulum Stress and Disease
- Erythrocyte Function and Pathophysiology
Lanzhou University
2018-2024
C-reactive protein (CRP) is a major acute phase and inflammatory marker, the expression of which largely liver specific highly inducible. Enhancers are regulatory elements critical for precise activation gene expression, yet contributions enhancers to pattern CRP have not been well defined. Here, we identify constitutively active enhancer (E1) located 37.7 kb upstream promoter human in hepatocytes. By using chromatin immunoprecipitation, luciferase reporter assay, situ genetic manipulation,...
: C-reactive protein (CRP) functions as a nonspecific marker in various inflammatory disorders, particularly evaluating the efficacy of pharmacological treatments patients with ulcerative colitis. The existing body evidence does not offer adequate support for direct implication CRP modulating advancement