Diana Carp
A5108773051- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
Centre hospitalier régional d'Orléans
2021-2025
PPM1D, a central regulator of the DNA damage response, is commonly mutated in therapy-related clonal hematopoiesis (CH), acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). PPM1D mutations have been shown to expand under selective pressure DNA-damaging chemotherapy. However, whether promote development hematologic malignancies remains unclear. We characterized clinical genomic profiles 112 PPM1D-mutated patients across spectrum disorders using combination bulk single-cell...
Whereas the prognosis of adult patients with Philadelphia-negative acute lymphoblastic leukemia (ALL) has greatly improved since advent pediatric-inspired regimens, impact initial central nervous system (CNS) involvement not been formerly re-evaluated. We report here outcome CNS included in prospective randomized GRAALL-2005 study. Between 2006 and 2014, 784 (aged 18-59 years) newly diagnosed ALL were included, whom 55 (7%) had involvement. In CNSpositive patients, overall survival was...