A5009840997- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Animal Disease Management and Epidemiology
- Multiple Myeloma Research and Treatments
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
Institut Gustave Roussy
2018-2025
Inserm
2021-2024
Sorbonne Paris Cité
2024
Université Paris Cité
2024
Université Paris-Saclay
2019-2021
Centre Hospitalier Universitaire de Martinique
2016-2018
PPM1D, a central regulator of the DNA damage response, is commonly mutated in therapy-related clonal hematopoiesis (CH), acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). PPM1D mutations have been shown to expand under selective pressure DNA-damaging chemotherapy. However, whether promote development hematologic malignancies remains unclear. We characterized clinical genomic profiles 112 PPM1D-mutated patients across spectrum disorders using combination bulk single-cell...
Adult T-cell Leukemia/Lymphoma (ATLL) is a sight- and life-threatening complication of human lymphotropic virus type 1 (HTLV-1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, lymphomatous infiltration. Orbital lesions are rare. We report the case an orbital tumor revealing systemic ATLL in 45-year-old Dominican patient who died despite treatment. Apart from late-grade cutaneous lymphoma, only T-lymphoma to develop orbit. Diagnosis based on...