A5088934800- Physiological and biochemical adaptations
- Renal and related cancers
- Genetics, Aging, and Longevity in Model Organisms
- Genetic and Kidney Cyst Diseases
- Spaceflight effects on biology
- Hedgehog Signaling Pathway Studies
University Hospital Cologne
2021-2024
University of Cologne
2021-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2024
Abstract The extracellular matrix (ECM) is a pivotal three-dimensional network crucial for tissue organization, cellular communication, and fundamental processes, where collagens are the major chemical entity in amount. ECM deregulation directly involved with several pathologies, such as tumour growth invasiveness, atherosclerosis, diabetic nephropathy. Mutations von Hippel-Lindau suppressor (pVHL) cause VHL syndrome, multi-tumour syndrome commonly associated clear cell renal carcinoma...
Abstract JADE family proteins (JADE1/2/3) have been implicated in diverse cellular functions and signaling pathways ranging from WNT cell cycle control to death complex transcriptional regulation through histone acetyl-transferase complexes. show a high degree of sequence similarity share two PHD zinc finger domains. JADE1 interacts with cilia-associated has cilia-related genetic disorders kidney phenotypes. However, the function widely expressed at molecular level is still elusive. Here we...