A5006023010- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Genetic Associations and Epidemiology
- Renal and related cancers
- Biological Research and Disease Studies
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Vasculitis and related conditions
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Congenital Diaphragmatic Hernia Studies
- Biomedical Ethics and Regulation
- Cerebrovascular and Carotid Artery Diseases
- Parvovirus B19 Infection Studies
- Autoimmune Bullous Skin Diseases
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Molecular Junctions and Nanostructures
- Respiratory viral infections research
- Chemical Reactions and Isotopes
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Diabetes Treatment and Management
- Plant Virus Research Studies
Shenzhen Second People's Hospital
2023-2025
Shenzhen University
2023-2024
Fudan University
1988
Université Libre de Bruxelles
1981
Background The currently available medications for treating membranous nephropathy (MN) still have unsatisfactory efficacy in inhibiting disease recurrence, slowing down its progression, and even halting the development of end-stage renal disease. There is a need to develop novel drugs targeting MN. Methods We utilized summary statistics MN from Kiryluk Lab obtained plasma protein data Zheng et al. performed Bidirectional Mendelian randomization analysis, HEIDI test, mediation Bayesian...
IgA nephropathy (IgAN) imposes a substantial burden of illness and death. However, systematic evaluation the impact COVID-19 pandemic on incidence pathology IgAN has yet to be performed. In this study, we analyzed kidney biopsy results from two medical institutions, covering timeframe January 2016 May 2023. We conducted statistical analyses various glomerular diseases according their corresponding pathological diagnoses. Our objective was compare different before during pandemic. The study...
Background: In primary membranous nephropathy (MN), 80% of patients harbor antibodies against phospholipase A2 receptor 1 (PLA2R1), closely linked to disease prognosis. Prior research has validated the correlation between directed towards cysteine-rich(CysR) and C-type lectin 1, 7, 8(CTLD1, CTLD7, CTLD8) domains PLA2R1 outcomes in MN. Methods: a prospective cohort 52 with newly diagnosed PLA2R1-MN, urine protein ≥ 3.5 g/24 hours estimated glomerular filtration rate ≥30 mL/min/1.73 m², we...
The frequency of mutants among the descendants intact parvovirus H-1 was increased when cells human and rat origin were exposed to UV light prior infection. An enhanced mutagenesis could be induced almost same extent in unirradiated by preinfecting them with or simian virus 40 that had been irradiated light. expression an after cell treatment UV-irradiated delayed, transient, dose-dependent, it dependent on de novo protein synthesis.
<title>Abstract</title> <bold>Objectives</bold> The Atherogenic Index of Plasma (AIP) value is relationship with the risk atherosclerosis, a known factor for cardiovascular events. However, studies on correlation between AIP and ischemic stroke (IS) in diabetic population Intensive Care Unit (ICU) are rare. Our study aimed to investigate values IS among patients American ICUs. <bold>Methods</bold> A multicenter retrospective cohort comprising 3695 from eICU-CRD v2.0 database 2014 2015 USA...
Abstract Background Membranous nephropathy (MN) has not yet been fully elucidated regarding its relationship with Type I and II Diabetes. This study aims to evaluate the causal effect of multiple types diabetes MN by summarizing evidence from Mendelian randomization (MR) study. Methods The statistical data for was obtained a GWAS encompassing 7,979 individuals. Regarding diabetes, fasting glucose, insulin, HbA1C data, we accessed UK-Biobank, within family consortium, MAGIC, Finnish database,...
Abstract Background Kidney diseases, including membranous nephropathy (MN), IgA (IgAN), and chronic kidney disease (CKD), pose significant global health challenges due to their high prevalence severe outcomes. There is still an urgent need discover new targets for treating diseases. Mendelian randomization (MR) has been widely used repurpose licensed drugs novel therapeutic targets. Thus, we aimed identify diseases analyze pathophysiological mechanisms potential side effects. Methods...
<title>Abstract</title> Background Idiopathic membranous nephropathy (IMN) is an autoimmune disease characterized by anti-PLA2R antibodies, which are linked to activity, prognosis, and relapse. While guidelines recommend immunosuppressive treatment for high antibody levels, the impact on PLA2R-negative patients remains unclear. Methods This study included 133 with positive histological PLA2R antigen baseline serum data. ELISA measured levels. Renal biopsy specimens were analyzed light...
The simian virus 40 (SV40)-transformed, newborn human kidney cell line NB-F was found to be heterogenous with respect its sensitivity parvovirus H-1. majority of the cells sustain a productive H-1 infection which eventually causes their lysis. Yet, small fraction appears much less susceptible Such resistance is stable, transmissible property this sub-population denoted NB-FR. heterogeneity also apparent from distribution karyotypes, bimodal and peaks at 114 46 chromosomes/cell. In contrast,...
Abstract Background The currently available medications for treating membranous nephropathy (MN) still have unsatisfactory efficacy in inhibiting disease recurrence, slowing down its progression, and even halting the development of end-stage renal disease. There is a need to develop novel drugs targeting MN. Methods We utilized summary statistics MN from Kiryluk Lab obtained plasma proteins Zheng et al., Decode, UKBioBank gene data eQTLgen GTEX. performed two-sample Bidirectional mediation...
Abstract Background Membranous nephropathy (MN), an autoimmune disease, has not yet been fully elucidated regarding its relationship with immune cells. Methods As a primary method in this Mendelian randomization (MR) analysis, we employed the Inverse Variance Weighted (IVW), Wald Ratio (WR), Steiger filtering, Median, mode, MR-Egger, pleiotropy residual sum, and outlier (MR-PRESSO) Leave-one-out sensitivity test. Reverse MR analysis was utilized to investigate whether MN affects Results...
Abstract Background Idiopathic membranous nephropathy (IMN) is a predominant cause of nephrotic syndrome among adults. Existing drugs are ineffective in about one-third IMN patients, and the high recurrence rate makes them far from satisfactory. Therefore, it imperative to find new therapeutic targets for nephropathy. Circulating inflammatory proteins plasma have been found be related disease prognosis yet causal relationship between still remains unclear. A better understanding response can...
Abstract Membranous nephropathy (MN) imposes a substantial burden of illness and death. However, systematic assessment the impact COVID-19 pandemic on MN incidence has not yet been conducted. This research is an observational cohort study conducted retrospectively. The kidney biopsy results two medical institutions, including our hospital, were reviewed for period between January 2016 May 2023. Relevant statistical analysis different glomerular diseases was performed based corresponding...