A5056891866- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Neonatal Health and Biochemistry
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Biomedical Research and Pathophysiology
- Radiomics and Machine Learning in Medical Imaging
- Veterinary Medicine and Surgery
- Cardiovascular Conditions and Treatments
- Neuroendocrine Tumor Research Advances
- Skin and Cellular Biology Research
- Biomedical and Engineering Education
- Fibroblast Growth Factor Research
- Optical Imaging and Spectroscopy Techniques
- COVID-19 and healthcare impacts
- Advanced Breast Cancer Therapies
IVC Evidensia
2024
Willows Veterinary Centre and Referral Service
2022-2024
Hospital Universitario Dexeus
2016-2023
Instituto Oncológico Dr. Rosell
2014-2022
Newbiotechnic (Spain)
2013
Instituto de Hematología e Inmunología
2008
Hospital Universitario de San Vicente Fundación
2004
University of Cambridge
1990
Universidad de Antioquia
1988
Edward Hines, Jr. VA Hospital
1979
Abstract Combination treatment with BRAF (BRAFi) plus MEK inhibitors (MEKi) has demonstrated survival benefit in patients advanced melanoma harboring activating mutations. Previous preclinical studies suggested that an intermittent dosing of these drugs could delay the emergence resistance. Contrary to expectations, first published phase 2 randomized study comparing continuous versus schedule dabrafenib trametinib a detrimental effect “on−off” schedule. Here we report confirmatory data from...
Serial analysis of BRAF mutations in circulating-free DNA (cfDNA) could be prognostic value melanoma patients. We collected blood samples from 63 advanced BRAFV600E/K patients and determined status cfDNA using a quantitative 5'-nuclease PCR-based assay. Levels mutation pre-cfDNAs were associated significantly with tumour burden, progression-free survival overall survival. Changes after initiation treatment (early-cfDNA) had significant correlation outcome. In persistent (n=12), 3.5 months...
ABSTRACT A polyradiculoneuritis and polymyositis caused by a toxoplasma‐like protozoan is described in two seven‐week‐old labrador pups. Examination of centrifuged sample cerebrospinal fluid was useful diagnostic aid one case the successful treatment other pup described. This discussed light recently Neospora caninum which can also affect neuromuscular system neonatal
Somatic copy number variations (CNV; i.e., amplifications and deletions) have been implicated in the origin development of multiple cancers some these aberrations are designated targets for therapies. Although FISH is still considered gold standard CNV detection, increasing potentially druggable to be assessed makes a gene-by-gene approach time- tissue-consuming. Here we investigated potential next generation sequencing (NGS) custom panels simultaneously determine CNVs across FFPE solid...
Genomic analysis of circulating tumor DNA (ctDNA) released from cancer cells into the bloodstream has been proposed as a useful method to capture dynamic changes during course disease. In particular, ability monitor epidermal growth factor receptor (EGFR) mutation status in cell-free (cfDNA) isolated advanced non-small cell lung (NSCLC) patients EGFR can help correct management disease and overcome challenges associated with heterogeneity insufficient biopsied material perform key molecular...
Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the with advanced solid tumors, about 20% respond very efficiently immunotherapy anti-PD1/PD-L1 antibodies achieve long lasting cancer responses. It is unclear whether an efficient cancer-specific immune response may also correlate upon Here, we explored antiviral mRNA-based vaccine BNT162b2 in of 11 long-lasting...
Background: Senescence is a well characterized effect of the CDK4-6 inhibitors, and senescent cells have been described to produce inflammatory mediators as part "senescence associated secretory phenotype (SASP)". We hypothesized that CDK4/6 following cell cycle arrest induction senescence can increase production by breast cancer cells, such IL-8, are known enhance activity anti-PD-L1 agents. Methods: Four lines were used in this study, HER2+ AU565, luminal A MCF-7and triple negative (TN)...
In a significant percentage of advanced non-small cell lung cancer (NSCLC) patients, tumor tissue is unavailable or insufficient for genetic analyses at time to progression. We prospectively analyzed the appearance alterations associated with resistance in liquid biopsies NSCLC patients progressing targeted therapies using NGS platform.A total 24 were included study, 22 tyrosine kinase inhibitors and two other treatments. Liquid samples obtained GeneReadTM QIAact Lung DNA UMI Panel, designed...
Abstract is not available.
Objectives A comparative assessment of systolic blood pressure (BP) measurement agreement and precision in two commonly used non-invasive BP devices was carried out conscious cats. Methods Systolic measurements were obtained from 50 cats as part their clinical investigations. All taken by the same operator performed according to American College Veterinary Internal Medicine (ACVIM) consensus guidelines. The cuff location size for paired measurements. order device use randomised, an arousal...
Abstract Introduction and Objectives: Gastric pancreatic cancers lack effective therapies, leading to low survival rates particularly in the metastatic setting. Fibroblast growth factor receptor 2 (FGFR2) amplification fusions with TACC2 appear 5.5% 2.1% of gastric tumors, respectively. In cancers, KRAS p.G12C mutation is limited 1-2% cases. FDA has recently approved drugs targeting both alterations, pemigatinib infigratinib for cholangiocarcinoma FGFR2 fusions; sotorasib adagrasib mutant...
Genetic and drug sensitivity assays on primary cultures are not only of basic but also translational interest could eventually aid oncologists in the selection treatments. However, cancer cells need to be identified differentiated from non-tumor always present cultures. Also, successive passages can change proportions these two subpopulations. In this study, we propose fluorescence situ hybridization (FISH) analysis cell smears determine presence tumor obtained patients carrying...
Las funciones perdidas de la laringe o tráquea se pueden reemplazar diferentes maneras; sin embargo, ninguna alternativa es fisiológica y los trasplantes quedan con dificultades funcionales autoestima que alteran calidad sus vidas, El Trasplante estos órganos una útil, pero deben cumplirse ciertos requisitos básicos en cuanto a revascularización, reinervación imunosupresión. primero logró el conocimiento territorios vasculares avances las técnicas quirúrgicas. para todavía no han superado...