A5051466660- Ferroptosis and cancer prognosis
- Blood disorders and treatments
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Graphene and Nanomaterials Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and biological activity
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer, Lipids, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Signaling Pathways in Disease
- Synthetic Organic Chemistry Methods
- Cancer therapeutics and mechanisms
Central South University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
State Key Laboratory of Natural Medicine
2022-2023
China Pharmaceutical University
2022-2023
Glutathione peroxidase 4 (GPX4) is a promising target to induce ferroptosis for the treatment of triple-negative breast cancer (TNBC). We designed and synthesized novel series covalent GPX4 inhibitors based on RSL3 ML162 by structural integration simplification strategies. Among them, compound C18 revealed remarkable inhibitory activity against TNBC cells significantly inhibited compared ML162. Moreover, it was identified that could notably with high selectivity increasing accumulation lipid...
Abstract Doxorubicin (DOX) is an effective anticancer agent, but its clinical utility constrained by dose‐dependent cardiotoxicity, partly due to cardiomyocyte ferroptosis. However, the progress of developing cardioprotective medications counteract ferroptosis has encountered obstacles. Protosappanin A (PrA), anti‐inflammatory compound derived from hematoxylin, shows potential against DOX‐induced cardiomyopathy (DIC). Here, it reported that PrA alleviates myocardial damage and dysfunction...
Abstract Background and Aims Heart failure (HF) is a leading cause of mortality worldwide characterized by significant co-morbidities dismal prognosis. Neutrophil extracellular traps (NETs) aggravate inflammation in various cardiovascular diseases; however, their function mechanism action HF pathogenesis remain underexplored. This study aimed to investigate the involvement novel VWF-SLC44A2-NET axis progression. Methods NET levels were examined patients with mouse models transverse aortic...
Natural products are a major source of anticancer agents and play critical roles in drug development. Inspired by the complexity-to-diversity strategy, novel deoxypodophyllotoxin (DPT) analogues were designed synthesized. Among them, compound C3 exhibited potent antiproliferative activity against four human cancer cell lines with IC50 values low nanomolar range. Additionally, it showed marked paclitaxel-resistant MCF-7 cells A549 cells. Moreover, can inhibit tubulin polymerization targeting...
We propose a nanocarbon-enabled hybridization strategy to construct pharmacologically cooperative nanodrugs for augmented cancer therapy based on pharmacophore in medicinal chemistry and the synthetic principles of nanocarbons.