A5064782191- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Spatial Neglect and Hemispheric Dysfunction
- Vestibular and auditory disorders
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- Ophthalmology and Eye Disorders
- Phagocytosis and Immune Regulation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
University Children's Hospital Zurich
2022-2024
University of California, San Diego
2023
University Hospital of Zurich
2016
University of Zurich
2016
Abstract Immunotherapy has evolved as a powerful tool for the treatment of B-cell malignancies, and patient outcomes have improved by combining therapeutic antibodies with conventional chemotherapy. Overexpression antiapoptotic lymphoma 2 (Bcl-2) is associated poor prognosis, increased levels been described in patients “double-hit” diffuse large lymphoma, subgroup Burkitt’s pediatric acute lymphoblastic leukemia harboring t(17;19) translocation. Here, we show that addition venetoclax (VEN),...
Abstract Transcriptional cofactors of the ETO family are recurrent fusion partners in acute leukemia. We characterized ETO2 regulome by integrating transcriptomic and chromatin binding analyses human erythroleukemia xenografts controlled depletion models. demonstrate that beyond its well‐established repressive activity, directly activates transcription MYB, among other genes. The ETO2‐activated signature is associated with a poorer prognosis but also myeloid lymphoid leukemia subtypes....
Abstract The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific domains and co-factors contributing leukemogenesis are poorly understood. Drug targeting a such as challenging. Our study reveals critical role conserved amino acid, proline, at position 199, located 3’ end PNT (pointed) domain, in ERG’s ability induce P199 necessary for promote self-renewal, prevent myeloid differentiation hematopoietic progenitor cells,...
Abstract Oncogenic fusion transcription factors (TFs) frequently drive hematopoietic malignancies by altering gene expression in key developmental programs. TCF3::HLF is a TF that characterizes rare, treatment-resistant subtype of B-cell acute lymphoblastic leukemia (t(17;19) TCF3::HLF-positive B-ALL). Despite its clinical significance, the mechanisms which induces are unclear. We used HiChIP mapping and genetic interference to analyze at 3D-genome level, revealing enhancer-promoter...
Abstract Mesenchymal stromal cells (MSCs) contribute to the microenvironment regulating normal and malignant hematopoiesis, thus may support subpopulations of cancer escape therapeutic pressure. Here, we engineered bone marrow MSCs express a synthetic CD19-sensor receptor detect display interacting primary CD19+ leukemia in coculture. This implementation provides versatile platform facilitating ex vivo drug response profiling coculture with high-sensitivity scalability.
The visual line bisection task (LBT) is sensitive to perceptual biases of visuospatial attention, showing slight leftward (for horizontal lines) and upward vertical errors in healthy subjects. It may be solved an egocentric or allocentric reference frame, there no obvious need for graviceptive input. However, other adjustments, such as the subjective vertical, otolith input integrated. We hypothesized that incorporated when performing LBT predicted reduced accuracy precision roll-tilted....
Mesenchymal stromal cells (MSCs) contribute to the microenvironment regulating normal and malignant hematopoiesis, thus may support subpopulations of cancer escape therapeutic pressure. Here, we engineered bone marrow MSCs express a synthetic CD19-sensor receptor detect display interacting primary CD19+ leukemia in coculture. This implementation provides versatile platform facilitating ex vivo drug response profiling coculture with high-sensitivity scalability.
Background: TCF3::HLF is a chimeric transcription factor generated by the t(17;19) translocation harbored rare subtype of B-cell acute lymphoblastic leukemia (ALL). The fusion protein rewires transcriptional regulation towards stem-like/myeloid lineage signature and promotes leukemogenesis this resistant fatal disease. However, mechanisms which regulates gene expression are not fully understood.. Aims: Based on ChIP-seq analysis revealing predominant association oncogenic with enhancer...