A5111289253- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Metal-Organic Frameworks: Synthesis and Applications
- Impact of Light on Environment and Health
- Ocular and Laser Science Research
- Polyoxometalates: Synthesis and Applications
- Viral Infections and Immunology Research
- Circular RNAs in diseases
- Crystallography and molecular interactions
- RNA modifications and cancer
Sichuan University
2024-2025
Jilin University
2024
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2024
West China Hospital of Sichuan University
2024
Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical understanding various cellular processes. However, RNA quaternary structures have been rarely reported. Comparative genomics analysis has identified families containing hundreds sequences adopt conserved secondary and likely fold into complex three-dimensional (3D) structures. We use cryo-electron microscopy (cryo-EM) determine from four families, including ARRPOF OLE forming dimers, ROOL GOLLD...
<title>Abstract</title> The group II introns are self-splicing ribozymes intervened between two exons that undergo excision and exon ligation through lariat formation, which considered as ancestral forms of spliceosomes. Circularly permuted (CP) comprise rearranged structural domains separated by tethered have been artificially designed long ago to generate branched intron circular products via back-splicing, whose natural occurrence has also recently identified. Although extensive studies...