A5082261467- Oral microbiology and periodontitis research
- RNA and protein synthesis mechanisms
- Oral Health Pathology and Treatment
- Gut microbiota and health
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Streptococcal Infections and Treatments
- Biochemical Analysis and Sensing Techniques
- Ubiquitin and proteasome pathways
- Oral health in cancer treatment
- Inflammatory mediators and NSAID effects
- Amoebic Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Flavonoids in Medical Research
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Salivary Gland Disorders and Functions
- Cancer, Stress, Anesthesia, and Immune Response
- Osteoarthritis Treatment and Mechanisms
- Antimicrobial Peptides and Activities
- Fatty Acid Research and Health
Sichuan University
2022-2025
State Key Laboratory of Oral Diseases
2022-2024
Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical understanding various cellular processes. However, RNA quaternary structures have been rarely reported. Comparative genomics analysis has identified families containing hundreds sequences adopt conserved secondary and likely fold into complex three-dimensional (3D) structures. We use cryo-electron microscopy (cryo-EM) determine from four families, including ARRPOF OLE forming dimers, ROOL GOLLD...
Fusobacterium nucleatum in colorectal cancer (CRC) tissue is implicated at multiple stages of the disease, while mechanisms underlying bacterial translocation and colonization remain incompletely understood. Herein, we investigated whether extracellular vesicles derived from F. (FnEVs) have impacts on colonization. In mice with colitis-related CRC, a notable enrichment FnEVs was observed, leading to significant increase intratumor by accelerated progression CRC. The clinical CRC tissues...
Protein acetylation is a common and reversible posttranslational modification tightly governed by protein acetyltransferases deacetylases crucial for various biological processes in both eukaryotes prokaryotes. Although recent studies have characterized many diverse bacterial species, only few been identified prokaryotes, perhaps part due to their limited sequence homology. In this study, we YkuR, encoded
No current pharmacological approach is capable of inhibiting the symptomatology and structural progression osteoarthritis. M1 macrophages activated synovial fibroblasts (SFs) mutually contribute to propagation joint pain cartilage destruction in Here, triamcinolone acetonide (TA) delivered simultaneously remodel functional phenotypes SFs, with apoptotic neutrophils membrane camouflaged liposome (termed “NM@Lip”). NM@Lip had high cellular uptake SFs. Furthermore, TA-loaded (TA-NM@Lip)...
Abstract Dental caries is the most common chronic infectious diseases around world and disproportionately affects marginalized socioeconomic group. Streptococcus mutans , considered a primary etiological agent of caries, must depend on coordinated physiological response to tolerate oxidative stress generated by commensal species within dental plaque, which critical aspect its pathogenicity. Here, we identified characterized novel TetR family regulator SMU_1361c, encoded TnSmu2 operon,...
Abstract Background: Non-mutational mechanisms were recently discovered leading to reversible drug tolerance. Despite the rapid elimination of majority tumor cells, a small sub-population ‘‘drug-tolerant’’ cells remain viable with lethal exposure, which may further lead resistance or relapse. Several signaling pathways are involved in local systemic inflammatory responses contributing drug-induced phenotypic switch. Results: In this study, we report Toll like receptor 4 (TLR4)-interacting...
To make preliminary exploration into the Golgi apparatus targeting of chondroitin sulfate-modified micelles (CSmicelles) co-loaded with pirarubicin (THP) and vinorelbine (VRL) in tumor cells, as well their vitro anti-tumor metastasis effect.The cellular uptake efficiency internalization mechanism CSmicelles 4T1 mouse breast cancer cell line were investigated by flow cytometry. Preliminary study cells was conducted co-localization experiment. Then, effect THP VRL (THP+VTL-CSmicelles) on...
Taste perception, initiated by activation of taste receptors in bud cells, is crucial for regulating nutrient intake. Genetic polymorphisms receptor genes cannot fully explain the wide individual variations sensitivity. Alternative splicing (AS) a ubiquitous posttranscriptional mode gene regulation that enriches functional diversity proteins. Here, we report identification novel variant sweet Tas1r2 (Tas1r2_∆e4) mouse buds and mechanism which it diminishes responses vitro vivo. Skipping exon...