A5114804077- interferon and immune responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Mosquito-borne diseases and control
- Synthesis and Biological Evaluation
- Plant biochemistry and biosynthesis
- NF-κB Signaling Pathways
- Organic Light-Emitting Diodes Research
- Cytokine Signaling Pathways and Interactions
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
- Parasite Biology and Host Interactions
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Neuroendocrine regulation and behavior
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Cancer-related molecular mechanisms research
China Pharmaceutical University
2024
Huazhong Agricultural University
2023
Fudan University
2022-2023
State Key Laboratory of Genetic Engineering
2022
Central South University
2019
Xiangya Hospital Central South University
2019
The University of Tokyo
2008-2009
DNA, whether it is microbe-derived or host-derived, evokes immune responses when exposed to the cytosol of a cell. We previously reported that DNA-dependent activator IFN regulatory factors (DAI), also referred as DLM-1/ZBP1, functions DNA sensor activates innate system. In present study, we examined regulation complex DNA-sensing system by DAI and other molecules. first show directly interacts with in vitro requires three DNA-binding domains for full activation vivo . artificially induced...
The activation of the innate immune responses by DNA exposed within cytosol has gained much attention and, in this context, several cytosolic sensors have been identified. However, previous studies revealed operation redundant and complex mechanisms it still remains to be clarified how DNA-mediated evocation diverse can achieved. Here we show that two RIG-I-like receptors (RLRs), RIG-I MDA5, known as RNA receptors, nonredundantly function lead selective type I IFN genes. We demonstrate...
Summary Pummelo ( Citrus maxima or grandis ) is a basic species and an important type for breeding in Citrus. used not only fresh consumption but also medicinal purposes. However, the molecular basis of traits unclear. Here, compared with wild citrus species/ ‐related genera, content 43 bioactive metabolites their derivatives increased pummelo. Furthermore, we assembled genome sequence variety purposes long history, ‘Huazhouyou‐tomentosa’ (HZY‐T), at chromosome level size 349.07 Mb....
Acute myeloid leukemia (AML) is a common hematopoietic malignancy with invasive activity. Drug resistance greatly contributes to the poor efficacy of chemotherapy in AML treatment. Recent research indicates that long non-coding RNAs (LncRNAs) regulates malignancy. Microarray analysis was used screen out related genes, and interaction between small nucleolar RNA host gene 5(SNHG5) miR-32, as well miR-32 DNAJB9. Quantitative real-time PCR (qRT-PCR) In situ hybridization(ISH) were determine...
As the most common vector only second to mosquitoes, ticks pose an increasing threat public health and cause economic losses. However, genomic variations of remain largely unknown. Here, we conducted first whole-genome sequencing-based analysis structural variation (SV) understand biology evolution ticks. We identified 8,370 11,537 SVs in 156 Haemaphysalis longicornis 138 Rhipicephalus microplus, respectively. Different from close relationship H. longicornis, R. microplus can be clustered...
P2X receptors, a subfamily of ligand-gated ion channels activated by extracellular ATP, are implicated in various physiopathological processes, including inflammation, pain perception, and immune respiratory regulations. Structural determinations using crystallography cryo-EM have revealed that the three-dimensional architectures different subtypes across species remarkably identical, greatly advancing our understanding activation mechanisms. However, structural studies yield paradoxical...
Schistosomiasis is a zoonotic parasitic disease caused by schistosome infection that severely threatens human health. Therapy relies mainly on single drug treatment with praziquantel. Therefore, there an urgent need to develop alternative medicines. The glutamate neurotransmitter in helminths involved many physiological functions interacting various cell-surface receptors. However, the roles and detailed regulatory mechanisms of metabotropic receptor (mGluR) growth development Schistosoma...