A5086812364- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Blood disorders and treatments
- HIV Research and Treatment
- Genetic factors in colorectal cancer
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Effects of Environmental Stressors on Livestock
- Infrastructure Maintenance and Monitoring
- Meat and Animal Product Quality
- HIV-related health complications and treatments
- Cell Adhesion Molecules Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- Metabolism, Diabetes, and Cancer
- Whipple's Disease and Interleukins
- Animal Behavior and Welfare Studies
- Bone health and treatments
- Leprosy Research and Treatment
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- Endometriosis Research and Treatment
- Pediatric health and respiratory diseases
The University of Western Australia
2024
Monash IVF
2013
The Royal Free Hospital
2000-2010
University College London
2000-2010
University of California, San Francisco
1998
Gladstone Institutes
1998
The University of Adelaide
1993
Australian Dental Association
1993
The thymus in adults infected with the HIV-1 is generally thought to be inactive, both because of age-related involution and viral destruction. We have revisited question thymic function adults, using chest-computed tomography (CT) measure tissue HIV-1-seropositive (n = 99) or HIV-1-seronegative 32) subjects, correlating these results level circulating CD4(+) CD8(+) T cells that are phenotypically described as naive emigrants. Abundant was detectable many (47/99) aged 20-59. Independent age,...
Summary We present three common variable immunodeficiency (CVID) patients with severe inflammatory bowel disease of unknown aetiology, resistant to steroid treatment, treated infliximab. After exclusion any infection, infliximab was given at a dose 5 mg/kg every 4 weeks for 3 month induction followed by 4–8 depending on clinical response. Two these had predominantly small disease; they both showed response weight gain and improvement quality life scores. The third patient large involvement...
STUDY QUESTIONDo human blastocysts which subsequently implant release factors that regulate endometrial epithelial cell gene expression and adhesion to facilitate receptivity?
Abstract Common variable immunodeficiency (CVID) is an heterogeneous syndrome characterized by decreased levels of serum Ig and recurrent bacterial infection. Here, we were interested to study whether a qualitative defect the affinity Ab maturation process could be combined low level in cohort 38 CVID patients. For this, designed novel rapid screening test for detection hypomutated V gene expressed memory B cells. This delineated subset 9/38 (23%) patients with abnormal pattern mutation. The...
Abstract The single nucleotide polymorphism (SNP) rs107856856, located in the tryptophan hydroxylase-2 gene, is associated with behavioural phenotype for sheep temperament measured at weaning. Here, we tested association between that SNP and physiological responses to stressors adult sheep. Two groups of sheep, one genotype A/A (calm genotype) other G/G (nervous were selected from 160 exposed, twice, an open-field arena isolation box test (IBT). During each repeat, behaviour (cortisol,...
Aims-Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency.This paper describes immunological consequences of human virus (HIV) infection in a patient with familial CVID subsequently treated highly active antiretroviral therapy (HAART).Methods-Serial measurements over 11 years serum immunoglobulins, specific antibodies to tetanus toxoid and pneumococcal polysaccharides, lymphocyte phenotypes, HIV viral load were made.Results-The recovered total IgG IgM,...
We report on a 6 year old patient with an unusual clinical presentation of WAS and oligoclonal proliferation TCRγδ + large granular lymphocytes (LGL). Flow cytometry demonstrated two distinct populations strongly decreased (WASP−) or normal expression levels WASP (WASP+), respectively. Molecular analysis confirmed splice site mutation in intron 2 the gene WASP- cells but not WASP+ cells. LGL were WASP+, suggesting that independent rare events, somatic revertant mosaicism expansion, have...
Summary Common variable immunodeficiency disorders (CVIDs) are a heterogeneous group of diseases characterized by hypogammaglobulinaemia and consequent susceptibility to infection. CVID patients commonly develop variety additional manifestations for which the causative factors not fully understood. Two such granulomatous disease enteropathy. Because ability predict complications would aid clinical management, we continue search possible modifier genes. NOD2 acts microbial sensor is involved...
The current treatment of primary antibody deficiency (PAD) is the early recognition condition and replacement immunoglobulin combined with prompt infections complications. route administration (intravenous or subcutaneous), dose frequency still vary between centres countries. Most in patients PAD are reduced but not entirely prevented by immunoglobulin, sinopulmonary accounting for bulk remainder. Although there have been reports meningitis before treatment, we describe first two cases...
A family with an unusual combination of B‐cell immunodeficiency, distal limb abnormalities, genitourinary malformations, and mild dysmorphic features has recently been described. Here, we report a second similar features, which also shows autosomal dominant inheritance. In affected individuals from both families, sequence analysis candidate gene HOXA13 did not identify mutation, there was no evidence microdeletion involving either or the HOXA cluster as whole. We further delineate phenotype...