A5067079293- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Economic and Financial Impacts of Cancer
PURPOSE Cyclin inhibitors plus endocrine therapy represent the reference standard for hormone receptor–positive (HR+)/human epidermal growth factor receptor 2–negative (HER2–) locally advanced or metastatic breast cancer (ABC). Efficacy results on hard end points such as overall survival come from well-designed randomized clinical trials (RCTs). However, a limitation of RCTs is low external validity, and their extrapolation to broader population may not be appropriate. Real-world studies can...
e15008 Background: Biological agents have presented variable results in the treatment of metastatic colorectal cancer. This study aim to evaluate effectiveness and safety monoclonal antibodies bevacizumab, cetuximab panitumumab associated or not chemotherapy this scenario. Methods: A systematic review metanaysis was performed based on observational cohort studies published following databases: MEDLINE/ Pubmed, LILACS, COCHRANE Library EMBASE, up march 2016. The outcomes assessed trial were...