A5031341023- HIV Research and Treatment
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Hepatitis C virus research
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
MRC University of Glasgow Centre for Virus Research
2022-2024
University College London
2021-2023
Centre for Innovation in Regulatory Science
2023
National Institute for Biological Standards and Control
2021
Enveloped viruses encode specialised glycoproteins that mediate fusion of viral and host membranes. Discovery understanding the molecular mechanisms have been achieved through structural analyses from many different viruses, yet some genera remain unknown. We employed systematic genome annotation AlphaFold modelling to predict structures E1E2 60 species in Hepacivirus, Pegivirus, Pestivirus genera. While predicted structure E2 varied widely, E1 exhibited a very consistent fold across genera,...
Summary Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism pathogenesis. Despite their importance, there is a fragmentary understanding of within the Flaviviridae ; for many species have not yet been identified, others, such as hepaciviruses, molecular mechanisms remain uncharacterised. Here, we combine comprehensive phylogenetic analyses with systematic protein structure prediction to survey across entire . We discover class-II systems,...
Due to increased and broadened screening efforts, the last decade has seen a rapid expansion in number of viral species classified into
Abstract Enveloped viruses encode specialised glycoproteins that mediate fusion of viral and host membranes. Discovery understanding the molecular mechanisms has been achieved through structural analyses from many different viruses, yet some genera remain unknown. We have employed systematic genome annotation AlphaFold modelling to predict structures E1E2 sixty species in Hepaci, Pegi Pestivirus genera. Whilst predicted structure E2 varied widely, E1 exhibited a very consistent fold across...
Abstract Due to increased and broadened screening efforts, the last decade has seen a rapid expansion in number of viral species classified into Hepacivirus genus. Conserved genetic features hepaciviruses suggest they have undergone specific adaptation evolved hijack similar host proteins for efficient propagation liver. Here, we developed pseudotyped viruses elucidate entry factors GB virus-B (GBV-B), first hepacivirus described an animal, closely related hepatitis C virus (HCV). GBV-B...