A5021197154- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Infection Control and Ventilation
- Helicobacter pylori-related gastroenterology studies
- Endometriosis Research and Treatment
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Silicone and Siloxane Chemistry
- Complement system in diseases
- Occupational Health and Performance
- Chemokine receptors and signaling
- COVID-19 and healthcare impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gastric Cancer Management and Outcomes
- Dental Research and COVID-19
- Galectins and Cancer Biology
- Musculoskeletal pain and rehabilitation
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
Second Xiangya Hospital of Central South University
2019-2025
Central South University
2019-2025
Shanxi Medical University
2020-2023
Shaanxi Provincial People's Hospital
2023
Shaanxi Provincial People's Hospital
2020-2023
Harbin Engineering University
2020
University of California, San Francisco
2018-2019
Peking University
2013-2015
Peking University People's Hospital
2013
ABSTRACT To summarise the clinical characteristics, radiological features, treatments and prognosis of patients with myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) overlapped NMDA receptor (NMDAR) encephalitis. We retrospectively analysed who exhibited dual positivity for MOG antibodies NMDAR in serum/CSF from Jan 2018 to Jun 2023. Ten MOGAD encephalitis were enrolled. The median age initial attacks was 23 (range: 10–43) years old. Common symptoms cortical...
Aquaporin-4-immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (herein called NMO) is an autoimmune disease of the central nervous system in which AQP4-IgG binding to AQP4 on astrocytes results complement-dependent astrocyte injury and secondary inflammation, demyelination, neuron loss. We previously reported evidence for a complement bystander mechanism early oligodendrocyte NMO. Herein, we tested hypothesis that injury, involves diffusion nearby cells activated...
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models Alzheimer's disease (AD) other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to impair bulk Aβ clearance AD, resulting increased amyloid deposition brain; however, this finding controversial. Here, we provide evidence support different novel role AD. We found that Aqp4 deletion...
Cellular injury in AQP4-IgG seropositive neuromyelitis spectrum disorder (herein called NMO) involves binding to astrocytes, resulting astrocyte by complement-dependent cytotoxicity (CDC) and antibody-dependent cellular (ADCC) mechanisms. The rapid disease progression, severe tissue damage, abundant leukocyte infiltration seen some NMO patients suggest a more direct mechanism for demyelination neurologic deficit than secondary from loss. Here, we report evidence an 'ADCC bystander mechanism'...
Objective The objective of this study is to explore the clinicopathological characteristics gastric cancer and precancerous conditions in patients with primary lymphoma.Methods We analyzed 474 cases lymphoma, mainly DLBCL MALT, from three clinical centres retrospectively, compared parameters lymphoma complicated cancer, conditions, or no complications.Results A total 5.1% were diagnosed including metachronous adenocarcinoma (3.2%) synchronous (1.9%). Of 14.6% had atrophy (14.6%), intestinal...
Abstract Objectives This study investigates the effects and mechanisms of intestinal microbiota transplantation on cerebral ischemia reperfusion injury in aged mice. Methods We constructed a middle artery occlusion model after fecal from young C57 mice to for 30 consecutive days via enema. The neurological deficit score, infarction volume, flora composition, IL‐17 levels colon, brain, serum were evaluated mice, that received transplantation. Moreover, we administered rIL‐17A through caudal...
Abstract Aim Fibromyalgia ( FM ) is a chronic disorder characterized by widespread musculoskeletal pain and fatigue. It less frequently diagnosed disease in C hina, thus hinese rheumatologists may have lower awareness of compared with colleagues W estern countries. The aim this study to investigate the perceptions analyze their therapeutic approach clinical practice. Method An anonymous questionnaire survey was conducted among nationwide sample at 15th N ational R heumatology onference 2010....
Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflammation. The increased NMO pathology in rodents deficient complement regulator protein CD59 following passive transfer AQP4-IgG has suggested the potential therapeutic utility increasing expression proteins.A cell-based...
Objective. To evaluate the impact of RA on work capacity and identify factors related to impairment in patients with RA.
Abstract Background Some gastrointestinal disorders may be associated with Helicobacter pylori infection, which not only affect maternal health, but also lead to adverse pregnancy outcomes. We aim explore the association between H. and in pregnant women. Materials Methods In total, 503 patients were retrospectively analyzed divided into pylori‐ uninfected group, infected or eradicated group. influence of on diseases during among groups, as well severity, symptoms, laboratory tests related...
To investigate control measures for COVID-19 pandemic in GIE centers China.This is a retrospective multi-center research, including seven centers. Data collection was from 1 February to 31 March 2020 and the same period 2019.There were total of 28 definite cases these hospitals. Six out arranged shut down on February, with mean number shutdown days 23.6 ± 5.3. The actual workloads only 10.3%-62.9% compared those last year. All had preoperative screening process. Epidemiological...
Abstract Objective: To summarize the clinical characteristics, radiological features, treatments, and prognosis of patients with myelin oligodendrocyte glycoprotein (MOG) antibody associated disease (MOGAD) overlapped NMDA receptor (NMDAR) encephalitis. Methods: We retrospectively analyzed who exhibited dual positivity for MOG antibodies NMDAR in serum/CSF from Jan 2018 to Jun 2023 Results: Ten MOGAD encephalitis were enrolled. The median age initial attacks was 23 (range: 10-43) years old....