A5007614960- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- Advanced Proteomics Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
Inserm
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Université Grenoble Alpes
2019-2025
Immunité et Cancer
2019-2024
Weatherford College
2022
Centre Hospitalier Universitaire de Grenoble
2021
Institut de Biosciences et Biotechnologies
2019
Institut pour l'avancée des biosciences
2019
Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiologic event. In this context, tumor-associated macrophages (TAM) have related to chemoresistance 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used treating cancers. Nevertheless, details mechanism are still poorly elucidated. current study, we report that specifically overexpress dihydropyrimidine dehydrogenase...
Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among various strategies have been developed to target these cells, blockade colony-stimulating factor 1 receptor (CSF-1R) is one most promising ones. Here, we characterize resulting state human exposed a CSF-1R kinase inhibitor. Using RNA sequencing and metabolomics approach, reprogramming monocyte-derived under targeting. We find inhibition able impair cholesterol synthesis, fatty acid...
Abstract Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among various strategies have been developed to target these cells, blockade CSF-1R receptor is one most promising one. Here, we characterize resulting state human exposed a kinase inhibitor. We find inhibition able impair cholesterol synthesis, fatty acid metabolism and hypoxia-driven expression dihydropyrimidine dehydrogenase, an enzyme responsible for 5-fluorouracil...
Abstract Pyrimidine analogs are part of the first-line chemotherapy regimen for gastrointestinal cancers. Trifluridine combined with tipiracil, a specific thymidine phosphorylase inhibitor, in TAS-102 has recently emerged as potential alternative face primary or secondary chemoresistance to 5-fluorouracil. Despite its promise, current study, we report that macrophage-specific overexpression results macrophage-induced is insensitive tipiracil inhibition. In addition, demonstrate human...
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Abstract Colon adenocarcinoma is characterized by an infiltration of tumor-associated macrophages (TAMs). TAMs are associated with a chemoresistance to 5-Fluorouracil (5-FU), but the mechanisms involved still poorly understood. In present study, we found that specifically overexpress dihydropyrimidine dehydrogenase (DPD) in hypoxia, leading macrophage-induced 5-FU inactivation drug. Macrophage DPD expression hypoxia translationally controlled cap-dependent protein synthesis complex eIF4F...
<p>Supplementary figures S1 to S7</p>
<p>Supplementary figures S1 to S7</p>
<p>supplementary materials and supplementary figure legends</p>
<div>Abstract<p>Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiologic event. In this context, tumor-associated macrophages (TAM) have related to chemoresistance 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used treating cancers. Nevertheless, details mechanism are still poorly elucidated. current study, we report that specifically overexpress...
<div>Abstract<p>Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiologic event. In this context, tumor-associated macrophages (TAM) have related to chemoresistance 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used treating cancers. Nevertheless, details mechanism are still poorly elucidated. current study, we report that specifically overexpress...
<p>supplementary materials and supplementary figure legends</p>
Macrophages are innate immune cells involved in a number of physiological functions ranging from responses to infectious pathogens tissue homeostasis. The various these related their activation states, which is also called polarization. precise molecular description polarizations priority the field macrophage biology. It currently acknowledged that multidimensional approach necessary describe how polarization controlled by environmental signals. In this report, we protocol designed obtain...
Macrophages are innate immune cells involved in a number of physiological functions ranging from responses to infectious pathogens tissue homeostasis. The various these related their activation states, which is also called polarization. precise molecular description polarizations priority the field macrophage biology. It currently acknowledged that multidimensional approach necessary describe how polarization controlled by environmental signals. In this report, we protocol designed obtain...