Marie‐Hélène Laverrière
A5014376397- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Biochemical and Molecular Research
- Immune cells in cancer
- Appendicitis Diagnosis and Management
- Occupational and environmental lung diseases
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Pleural and Pulmonary Diseases
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Soft tissue tumor case studies
- Gallbladder and Bile Duct Disorders
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Cardiac tumors and thrombi
- Cancer Immunotherapy and Biomarkers
- Diagnosis and treatment of tuberculosis
- Vascular Tumors and Angiosarcomas
- Chemokine receptors and signaling
Centre Hospitalier Universitaire de Grenoble
2006-2025
Inserm
2001-2025
Université Grenoble Alpes
2010-2025
Centre National de la Recherche Scientifique
2021-2024
Immunité et Cancer
2021-2024
Weatherford College
2022
Institut de Biosciences et Biotechnologies
2021
Institut pour l'avancée des biosciences
2021
Hôpital Lyon Sud
2016
Hôpital Albert Michallon
2001-2014
High-grade appendiceal mucinous neoplasm (HAMN) is used to describe a rare epithelial of the appendix characterized by pushing-type invasion and high-grade cytologic atypia. Its implications regarding lymph node spread necessity right colectomy are currently debate. The objective present study was assess clinicopathologic characteristics, risk peritoneal metastasis, long-term outcomes patients diagnosed as HAMN in comparison low-grade (LAMN) adenocarcinoma, treated hemicolectomy. A total 443...
Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiologic event. In this context, tumor-associated macrophages (TAM) have related to chemoresistance 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used treating cancers. Nevertheless, details mechanism are still poorly elucidated. current study, we report that specifically overexpress dihydropyrimidine dehydrogenase...
Abstract Background Ovarian pseudomyxoma peritonei (OPMP) are rare, without well-defined therapeutic guidelines. We aimed to evaluate cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) treat OPMP. Methods Patients from the French National Network for Rare Peritoneal Tumors (RENAPE) database with proven OPMP treated by CRS/HIPEC histologically normal appendix digestive endoscopy were retrospectively included. Clinical follow-up data collected. Histopathological...
Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among various strategies have been developed to target these cells, blockade colony-stimulating factor 1 receptor (CSF-1R) is one most promising ones. Here, we characterize resulting state human exposed a CSF-1R kinase inhibitor. Using RNA sequencing and metabolomics approach, reprogramming monocyte-derived under targeting. We find inhibition able impair cholesterol synthesis, fatty acid...
The cytologic diagnosis obtained by brushing or biopsy in malignant biliary strictures is considered to be highly specific but poorly sensitive. diagnostic association of and bile exfoliate cytology has been suggested rarely performed clinical practice. objective this study was assess the performance aspiration associated with during therapeutic endoscopic retrograde cholangiopancreatography (ERCP).From 2004 2009, 239 consecutive patients who underwent ERCP were included study. clinically...
Abstract Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among various strategies have been developed to target these cells, blockade CSF-1R receptor is one most promising one. Here, we characterize resulting state human exposed a kinase inhibitor. We find inhibition able impair cholesterol synthesis, fatty acid metabolism and hypoxia-driven expression dihydropyrimidine dehydrogenase, an enzyme responsible for 5-fluorouracil...
BACKGROUND The diagnosis of well‐differentiated adenocarcinoma on bile aspiration is a well‐known challenge. This study was aimed at improving the diagnostic performance and providing biliary cytology learning atlas. METHODS single‐center, retrospective included 135 cases informative samples collected between 2009 2018 that were classified as benign, atypical, or malignant. A double assessment performed by novice cytopathologist experienced in to establish specificities, sensitivities,...
Background: The advent of Deep Learning initiated a new era in which neural networks relying solely on Whole-Slide Images can estimate the survival time cancer patients. Remarkably, despite deep learning’s potential this domain, no prior research has been conducted image-based analysis specifically for peritoneal mesothelioma. Prior studies performed statistical to identify disease factors impacting patients’ time. Methods: Therefore, we introduce MPeMSupervisedSurv, Convolutional Neural...
Abstract Pyrimidine analogs are part of the first-line chemotherapy regimen for gastrointestinal cancers. Trifluridine combined with tipiracil, a specific thymidine phosphorylase inhibitor, in TAS-102 has recently emerged as potential alternative face primary or secondary chemoresistance to 5-fluorouracil. Despite its promise, current study, we report that macrophage-specific overexpression results macrophage-induced is insensitive tipiracil inhibition. In addition, demonstrate human...