A5005031809- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hematological disorders and diagnostics
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Neutropenia and Cancer Infections
- Multiple and Secondary Primary Cancers
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- BRCA gene mutations in cancer
King Hussein Cancer Center
2014-2025
University of Jordan
2023-2025
Hospital de Especialidades
2023
Instituto Nacional do Câncer
2023
Newcastle University
2023
Instituto de Investigación Biomédica de Salamanca
2023
Saint Michael's Medical Center
2012
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. Osimertinib established as a standard of care patients with common sensitizing EGFR-mutant advanced non–small-cell...
Background/Objectives: This study evaluates the diagnostic accuracy of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) using bone marrow biopsy (BMB) and clinical follow-up as reference standards. It further identifies predictive factors for involvement (BMI) in non-Hodgkin lymphoma (NHL) patients. Methods: NHL patients who underwent [18F]FDG PET BMB at diagnosis a tertiary cancer center were included this study. Diagnostic was analyzed, logistic regression performed to...
DTC accounts for the majority of endocrine tumors. While incidence thyroid cancer has been increasing globally over past few decades, papillary carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to assess 5- and 10-year overall survival (OS) progression-free (PFS) 528 Arabic patients diagnosed primary from 1998 2021. Additionally, analyze impact various factors on both OS PFS. An univariable analysis was...
Abstract Background Staging of non-small-cell lung cancer (NSCLC) is a multidisciplinary process involving imaging, endoscopic and surgical techniques. This study aims at investigating the diagnostic accuracy 18 F-FDG PET/CT, CT scan, endobronchial ultrasound/transbronchial needle aspirate (EBUS/TBNA) in preoperative mediastinal lymph nodes (MLNs) staging NSCLC. Methods We identified all patients who were diagnosed with NSCLC King Hussein Cancer Center Amman, Jordan, between July 2011...
2-Deoxy-2-[ 18 F]fluoro- d -glucose PET/computed tomography ([ F]FDG PET/CT) has proven to be a sensitive method for the detection and evaluation of hematologic malignancies, especially lymphoma. The increasing incidence mortality rates leukemia have raised significant concerns. Through utilization whole-body imaging, [ PET/CT provides thorough assessment entire bone marrow, complementing limited insights provided by biopsy samples. In this regard, ability assess diverse types been found...
extramedullary acute myeloid leukemia (eAML) is characterized by tumor formation infiltrated blasts, with or without maturation and effaced architecture. The clinical, genetic molecular aspects overall outcomes are well defined worldwide, but not in our region.This a retrospective single center cohort study on 32 patients, who were identified over 10 years to the pathologic genetic-molecular aspects, survival outcomes.eAML rare (1%), occurs at younger age male predominance. Central nervous...
Dasatinib, which is an inhibitor of BCR-ABL and SRC family tyrosine kinases, used for the treatment patients with Philadelphia chromosome (Ph) positive leukemia, especially those who develop resistance or are intolerant to imatinib. The most common adverse effects attributed its use are: myelosuppression, nausea, diarrhea, peripheral edema. Hemorrhage, could be gastrointestinal, genitourinary central nervous system, a less frequent effect. In this case, we report patient affected by...
Generic imatinib therapy is being globally considered owing to cost considerations. However, evidence of its efficacy and safety in Middle Eastern clinical settings scarce.The generic (Cemivil) were assessed among Jordanian patients diagnosed with chronic myeloid leukemia using an observational, multicenter, prospective study design. Responses defined European LeukemiaNet 2009 guidelines by complete blood counts, fluorescence situ hybridization, real-time quantitative polymerase chain...
Background This study aims to evaluate real-world (rw) outcomes of immunotherapy (IO) for advanced stage NSCLC at King Hussein Cancer Center (KHCC) in Jordan. Methods Advanced patients who received IO KHCC between 2017 and 2022 were included. The data retrospectively collected. PFS OS estimated with ECOG performance status (ECOG PS) 0-1. Cox regression analyzed predictors first-line (1L) IO, regardless status. Results total number included was 244. Out those, 160 (65%), 67 (28%), 17 (7%) as...
Patterns and predictors of relapse in primary gastric diffuse large B cell lymphoma (DLBCL) were variably reported. Our study aims to evaluate the patterns early-stage DLBCL treated with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone (RCHOP).From 2005 2019, medical records 72 patients stage I or II six cycles RCHOP without radiotherapy reviewed. Different variables correlated progression free survival (PFS), overall (OS), local (LRFS).64 (88.1%) achieved a complete...
6566 Background: Immune checkpoint inhibitors (ICIs) are standard of care nowadays in the treatment many solid tumors as single agent or combination. Recent literature suggested increased use ICI near end life; our aim was to find characteristics patients who received 30 days less before their death. Methods: Data with advanced have (ICI) therapy and died disease were retrospectively retrieved. Patients categorized into those dying within last dose receiving more than Variables potential...
We present a rare case of intussusception in 41-year-old man with acute myeloid leukemia without an evidence leukemic infiltration the bowel. The patient presented to emergency room right lower quadrant pain. Initially he was diagnosed typhlitis. CT scan done and showed ileocolic definitive lead point identified. Patient underwent hemicolectomy histopathological study specimen did not show any infiltrate. High suspicion should be kept mind patients presenting abdominal
The effective development of COVID-19 vaccination has mitigated its harm. Using two laboratory methods, we investigated the efficacy BNT162b2 mRNA and BBIBP-CorV vaccines on seroconversion rates in cancer patients undergoing active treatment.SARS-CoV-2 were scheduled for 134 individuals. consenting participants submitted three venous blood samples. Three samples: T0, T1, T2. ABBOTT-SARS-CoV-2 IgG II Quant Elecsys® Anti-SARS-CoV-2 assays used to evaluate samples convert antibody titers WHO...
Renal cell carcinoma (RCC) is a significant cause of mortality worldwide. To date, many atypical metastatic sites have been observed and reported in patients with RCC. However, to the best our knowledge, there no cases thyroid cartilage metastasis context RCC metastasis. Herein, we present case 68-year-old man who developed left arm pain that led an diagnosis. First, evaluation by pan-computed tomography (CT) denoted right kidney identified humeral Subsequently,
We present a rare case of high-grade spindle cell liver carcinoma investigated using