A5038350908- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
- COVID-19 Impact on Reproduction
- Estrogen and related hormone effects
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
King Hussein Cancer Center
2016-2025
University of Jordan
2023
Jordan University of Science and Technology
2014
Ministry of Health
2014
Makassed General Hospital
2002
Al-Quds University
2002
University of Massachusetts Chan Medical School
1992
Hôpital Beaujon
1992
Brigham and Women's Hospital
1992
Pitié-Salpêtrière Hospital
1992
Telomerase (hTER and hTERT) plays a crucial role in cellular immortalization carcinogenesis. activity can be detected about 85% of different malignant tumors, but is absent most normal cells. In situ hybridization analysis showed that high levels hTER hTERT expression are present bladder cancer, while no signal was tissue. Therefore, this work we propose to use transcriptional regulatory sequences control the cytotoxic gene tumor cells, resulting selective destruction cell population....
OBJECTIVES: To evaluate the effect of procalcitonin-guided management on duration antibiotic therapy in critically ill cancer patients with sepsis. DESIGN: Randomized, controlled, single-blinded trial. SETTING: A comprehensive multidisciplinary hospital Jordan. PATIENTS: Adults treated ICU who were started antibiotics for suspected infection, met SEPSIS-3 criteria, and expected to stay greater than or equal 48 hours. INTERVENTIONS: Patients randomized standard care (SC) arms. All had...
Pilocytic astrocytoma (PA) is one of the most common glial neoplasms in pediatric population, and its gross total resection can be curative. Treatment partially resected or recurrent tumors challenging, factors associated with increased recurrence risk are not well defined. Identification favorable unfavorable lead to a better understanding management patients PA. We studied pathologic characteristics 116 intracranial PAs from 4 institutions representing 3 distinct geographic regions...
Poor graft function (PrGF) is a serious complication of allogeneic hematopoietic cell transplantation (allo-HCT), and current therapies are only partially effective. Eight published reports on the effect eltrombopag PrGF showed encouraging results. This study aimed to assess safety efficacy for treatment after allo-HCT. A retrospective was conducted 23 patients with following allo-HCT at King Hussein Cancer Center (KHCC), Amman, Jordan between January 2013 December 2023. The patient-,...
Background: Cytomegalovirus (CMV) infection can lead to significant morbidity and mortality in pediatric hematopoietic stem cell transplant recipients. Early detection of CMV is crucial for managing its impact. Aim: This study aims evaluate the effectiveness QuantiFERON-CMV ® (QF-CMV) QuantiFERON-Monitor (QFM) tests predicting graft-versus-host disease (GvHD) recipients enhance patient outcomes support personalized prevention strategies. Methods: The QF-CMV QFM were used predict pp65 antigen...
In Jordan, lung cancer ranks as the second most common tumor, and there is an urgent need to explore genetic landscape of cancer. This study aimed identify actionable mutations in samples Jordanians by targeted next-generation sequencing (NGS) investigate correlations with clinical pathological parameters. Totally, 121samples were prepared for NGS DNA extractions from formalin-fixed paraffin-embedded (FFPE) blocks, followed library preparation using AmpliSeq Colon Lung panel, which covers...
Seroprevalence studies of SARS-CoV-2 antibodies are useful in assessing the epidemiological status community, and degree spread.To study seroprevalence rates among healthy blood donors Jordan, at various points time as pandemic evolves community.In total, 1374 donor samples, from three groups, were tested for total immunoglobulin antibodies. In first group, samples 734 individuals (from donations made between January June 2020) June. second 348 September 2020. The third group 292 was...
Pathologists use certain terminologies to communicate uncertainty in pathology reports. The message conveyed reports may be interpreted differently by clinicians leading possible miscommunication. We aimed compare the interpretation and impact of phrases between pathologists clinicians. A survey with examples uncertain diagnoses containing ("suspicious for", "indefinite "favor", "cannot exclude", "suggestive of", "compatible with", rule out", "highly suspicious for" "consistent with") was...
One of the most frequently used methods for quantifying PD-L1 (programmed cell death-ligand 1) expression in tumor tissue is IHC (immunohistochemistry). This may predict patient's response to anti-PD1/PD-L1 therapy cancer.
Background KRAS and NRAS gene mutations are frequently observed in childhood leukemia. The objective of this study was to determine the frequency RAS association between other genetic aberrations Arab Asian children with acute lymphoblastic leukemia (ALL) or myeloid (AML). Methods Diagnostic samples 485 patients (<18 years) from Iraq Jordan were obtained, using Flinders Technology Associates filter papers. Polymerase chain reaction direct sequencing performed Japan. Results detected 86/318...
Dysregulation in the miRNA-21 expression has been previously observed a number of malignancies and not only tumor cell itself but also body fluids cancer patients. The present study aimed to find out clinical significance cell-free circulating as an efficient non-invasive biomarker for screening lung case-control included plasma samples from 80 patients healthy controls. Magnetic bead technology was used miRNA isolation advanced TaqMan assays were quantification level individuals.The overall...
Viral cause of sporadic breast cancer (SBC) has been suggested based on the experimental murine model mammary tumor caused by mouse virus (MMTV), Epstein-Barr (EBV), and human papillomavirus (HPV). While some studies have demonstrated presence viral sequences MMTV, HPV, EBV in cells, others failed. These contradictions may be attributed to geographical distribution incidence and/or technical variations. In current study, we aimed investigate correlation infections with development Jordanian...
Abstract Background Covid-19 seroprevalence rates and serological tests are important tools in understanding the epidemiology of disease help fight against it. Seroprevalence vary according to population studied test employed they range from 0.133 25.7%. The purpose this study is assess rate a healthy blood donors living under strict lockdown measures Jordan which has total 144 confirmed cases per million population. Methods Left-over sera plasma samples 746 were tested using commercially...
Human epidermal growth factor receptor 2 (HER2), a promising therapeutic target, can be mutated, amplified, or overexpressed in different malignancies, including non-small cell lung cancer (NSCLC). Although these alterations showed adverse prognostic effects many cancers, their clinical significance NSCLC is controversial. This study primarily assessed the prevalence of HER2 protein expression among Jordanian patients. In addition, possible association between and clinicopathological...
Malignant rhabdoid tumor (MRT) of the liver is a rare malignancy with grave prognosis. This entity should be considered in differential diagnosis any aggressive low levels alpha fetoprotein. We report 2 cases hepatic MRT presenting infancy. In these cases, we show that loss INI1 facilitates making correct primary utilizing BAF 47 (INI1 gene product) immunostains. Difficulty encountered this diagnosis, including need for repeated biopsies, can avoided if early on and immunohistochemistry ordered.