A5031301010- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune cells in cancer
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
Third Xiangya Hospital
2022-2025
Central South University
2022-2025
Xiangya Hospital Central South University
2023-2025
Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide, especially in advanced stages where limited treatment options result poor prognosis. The immunosuppressive tumor immune microenvironment (TIME), characterized by low cell infiltration and exhaustion, limits immunotherapy efficacy. To address this, our study investigates the role C-C motif chemokine ligand 3 (CCL3) modulating HCC TIME. Methods We analyzed CCL3 expression human samples from...
Hepatocellular carcinoma (HCC) resists immunotherapy due to its immunosuppressive microenvironment. Sarcoma homology 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) inhibits T cell receptor signaling, and pharmacological inhibition is limited by poor selectivity membrane permeability. Here, we generated CRISPR-edited SHP-1-knockout (KO) CD8+ cells enhance adoptive therapy against HCC. Single-cell RNA sequencing of HCC patient revealed elevated SHP-1 in exhausted subsets. SHP-1-KO...
Tumor heterogeneity of immune infiltration cells plays a decisive role in hepatocellular carcinoma (HCC) therapy response and prognosis. This study investigated the effect different subtypes CD8+T on HCC tumor microenvironment about its
Background: There is increasing evidence that protein ubiquitination plays crucial roles in adaptive immune response by regulating the function of T cells. Zinc finger 91 (ZFP91), as an E3 ubiquitin (Ub) ligase, has been shown to be associated with proliferation and activation mouse derived tumor infiltrating lymphocytes. However, whether it functions human cells underlying mechanism still need further exploration. Methods: We used lentivirus infection H9 cell lines primary reduce ZFP91...