A5071298679- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Inflammatory Bowel Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Neonatal Health and Biochemistry
- Infant Nutrition and Health
- IL-33, ST2, and ILC Pathways
- Ocular Surface and Contact Lens
- Gastrointestinal motility and disorders
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
University of Electronic Science and Technology of China
2020-2024
Glaucoma is the leading cause of irreversible blindness. Currently, most therapeutic strategies aim to reduce elevated intraocular pressure (EIOP), but this does not always halt disease progression. Evidence suggests a role for T cells in glaucoma pathogenesis, underlying mechanisms remain largely unknown. Here, we found that percentage circulating CD4 + expressing gut-homing integrin β7 was increased patients with and associated stage. In an EIOP-triggered mouse model, infiltrated retina...
Irritable bowel syndrome (IBS) is characterized with abdominal pain, bloating, and changes in habits, dealing IBS still a clinical challenge. The pathogenesis of has been reported to be linked low-grade mucosal inflammation, macrophages contribute the pathological process this disease. Kurarinone (KAR), flavanoid derived from Sophora flavescens, found medically effective many inflammatory conditions cancers. KAR was previously inhibit LPS-induced expression cytokines macrophages, whether how...
Abstract Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical significance, underlying mechanisms glaucoma pathogenesis remain poorly understood. In this study, we aimed unravel multifaceted nature investigating interaction between T retinas. By utilizing samples, murine models, cell transfer made several key findings. Firstly, observed that...
Objective To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing clinical utility of Lf in glaucoma. Methods A cross-sectional study involved 161 glaucoma patients 115 healthy controls, with a follow-up 14 subjects after approximately 2 years. Plasma markers were quantified using ELISA, comparing levels analyzing across different severity grades. Results Glaucoma had significantly elevated compared to controls ( p < 0.001). Higher correlated more severe...
Extra-intestinal manifestations (EIMs) of the eyes are found in IBD patients, but underlying pathogenesis remains unknown. To investigate IBD-associated retinal dysfunction, chronic colitis was induced mice by oral administration dextran sodium sulfate (DSS). Electroretinography (ERG) performed to evaluate function. Retinal neuron degeneration analyzed immunohistochemistry. Colitic displayed aberrant amplitudes ERG a-, b-wave and oscillatory potentials (OP). Importantly, we observed severe...
Aim: To investigate the association between plasma AAT level and glaucoma. Methods: 163 glaucoma patients 111 healthy controls were recruited. The levels measured by ELISA. Results: Plasma was significantly higher in than those (p < 0.001). Patients with exhibited severer disease stage (early vs. severe: p 0.05; H-P-A; early end-stage: 0.01; AGIS). ROC curves yielded that can distinguish from advanced AUC: 0.616; 0.763; 0.660; Conclusion: is a useful biomarker for identification of severity.
Glaucoma is a group of retinal neurodegenerative diseases causing irreversible visual impairment. The pathogenesis this disease complicated. Studies have shown that the immune system involved in process glaucoma. There are continuous evidences autoantibodies play crucial role However, focuses on B cells, antibody-producing cells glaucoma surprisingly limited.Fresh peripheral blood samples were collected from 44 patients (38 with primary angle-closure (PACG) and 6 (primary open-angle POAG))...
Objective: Evidence suggests that dysbiosis of the gut microbiota plays a pivotal role in development glaucoma.This is commonly associated with chronic intestinal inflammation and increased permeability.However, understanding permeability glaucoma remains insufficient.This study aims to investigate potential relationship between fecal markers glaucoma.Methods: We recruited 114 patients 75 healthy controls.Levels lactoferrin (Lf) alpha-1 antitrypsin (AAT) were quantified using enzyme linked...
Objective: The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. Methods: A total 144 glaucomatous patients 66 healthy controls were enlisted for study. calprotectin assessed using enzyme-linked immunosorbent assay. Results: median levels significantly elevated in (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure (76.85 0.001) open-angle (69.29 = 0.016) groups compared with controls. notable proportion (24%; (21%; subgroups...