A5102844956- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Prostate Cancer Treatment and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Guidance and Control Systems
- Radiomics and Machine Learning in Medical Imaging
- Kruppel-like factors research
- Advanced X-ray and CT Imaging
- Robotic Path Planning Algorithms
- Occupational and environmental lung diseases
- Cancer-related gene regulation
- Medical Imaging and Analysis
- High Altitude and Hypoxia
- Control and Dynamics of Mobile Robots
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Prostate Cancer Diagnosis and Treatment
- Distributed Control Multi-Agent Systems
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell death mechanisms and regulation
- Intracranial Aneurysms: Treatment and Complications
- Acute Myeloid Leukemia Research
Institute of Hematology & Blood Diseases Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Taichung Veterans General Hospital
2015-2024
Southern University of Science and Technology
2021-2024
Henan Institute of Science and Technology
2024
Beijing Institute of Technology
2021-2023
Beijing Haidian Hospital
2023
Tianjin Normal University
2019
Dalian Medical University
2016-2018
Second Affiliated Hospital of Dalian Medical University
2016
Inactivation of phosphatase and tensin homolog (PTEN) is prevalent in human prostate cancer causes high-grade adenocarcinoma with a long latency. Cancer-associated fibroblasts (CAFs) play pivotal role tumor progression, but it remains elusive whether how PTEN-deficient cancers reprogram CAFs to overcome the barriers for progression. Here, we report that PTEN deficiency induced Krüppel-like factor 5 (KLF5) acetylation interruption KLF5 orchestrated intricate interactions between cells enhance...
Objective— Hypoxic pulmonary hypertension (HPH) is characterized by proliferative vascular remodeling. Abnormal artery smooth muscle cells proliferation and endothelial dysfunction are the primary cellular bases of AQP1 (aquaporin-1) regulated oxygen level has been observed to play a role in migration cells. The HPH pathogenesis not directly determined date. To determine possible roles explore its mechanisms. Approach Results— Aqp1 knockout mice were used, model was established this study....
Abstract Background Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant available therapies, leading death of patients. Enriched in TGF-β plays a pivotal role metastasis development. However, directly targeting or its receptors has been challenging for treatment metastasis. We previously found that induces then depends on acetylation transcription factor KLF5 at K369 regulate multiple biological processes, including...
Hepatocellular carcinoma (HCC) is a common malignancy with higher mortality, and means are urgently needed to improve the prognosis. T cell exclusion (TCE) plays pivotal role in immune evasion, lncRNAs represent large group of tumor development progression modulators. Using TCGA HCC dataset (n=374), we identified 2752 differentially expressed 702 TCE-associated lncRNAs, which 336 were both groups. As using univariate Cox regression analysis, those associated overall survival (OS) subjected...
Abstract Background The diagnostic process for fibrotic interstitial lung disease (F-ILD) is notably intricate, necessitating a multidisciplinary discussion to achieve consensus based on both clinical and radiological features. This study investigated the shared distinctive long-term mortality predictors among two primary phenotypes of F-ILD, namely idiopathic pulmonary fibrosis (IPF) connective tissue disease-associated (CTD-ILD). Methods We included patients with F-ILD diagnosed from...
Our aim is to demonstrate a rare cause of hemoperitoneum without vaginal bleeding resulting from the rupture uterine artery pseudoaneurysm after uncomplicated delivery.
In recent years, quadrotor drones have gained more and attraction both in industry research. Position control is critical to quadcopter flight control. Its performance highly related collision avoidance, therefore safety critical. Among various approaches, model predictive attention by its systematic way of addressing optimal objective system constraints states inputs. However, the (MPC) approach inherently based. It cannot guarantee good under condition inaccurate or purturbed plant. this...
<h3>BACKGROUND:</h3> Cardiopulmonary exercise testing (CPET) is a unique diagnostic tool that assesses the functional capacity of heart, lungs, and peripheral oxidative system in an integrated manner. However, clinical utility CPET for evaluating interstitial lung disease (ILD) remains uncertain. The objective this study was to determine predictive value mortality subjects with ILD. <h3>METHODS:</h3> We prospectively enrolled ILD who underwent at tertiary medical center Taiwan followed up...
Abstract Background The prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly understood. Methods We investigated associations EC with PCa recurrence castration resistance 8 bulk transcriptomic 4 single-cell RNA-seq cohorts. A recurrence-associated (RAEC) signature was constructed by comparing 11 machine learning algorithms through nested cross-validation. Functional relevances RAEC-specific genes were also tested. Results subset...
Time-resolved magnetic resonance angiography (TR MRA) is a promising less invasive technique for the diagnosis of intracranial vascular lesions and hypervascular tumors. Similar to 4-dimensional computed tomographic obtaining high frame rate images, TR MRA utilizes acceleration techniques acquire sequential arterial venous phase images identifying, localizing, classifying lesions. Because good agreement with digital subtraction grading brain arteriovenous malformations Spetzler-Martin...
As the number of elderly population increase, prostate cancer (CaP) becomes most common cause urological men in Taiwan. Multiparametric MRI (mp-MRI) combines standard pulse sequences and Functional Imaging, is a promising tool for CaP detection. Its role has changed from detection to preoperative staging. A consensus scoring system, PI-RAD™, developed interpretation reporting.
Abstract Both androgen receptor (AR) and the ZFHX3 transcription factor modulate prostate development. While AR drives prostatic carcinogenesis, is a tumour suppressor whose loss activates PI3K/AKT signalling in advanced cancer (PCa). However, it unknown whether are functionally related PCa cells and, if so, how. Here, we report that AR‐positive LNCaP C4‐2B cells, upregulates via androgen‐induced binding to androgen‐responsive elements (AREs) of promoter. Androgen also upregulated vivo, as...
Motivation: Could lumbar fat and water MRI be as an opportunistic screening tool?Goal(s): To develop autoML radiomics-Based Classification for osteoporosis prediction using MRI. Approach: A TPOP-radiomics classification model was trained images obtained through the IDEAL-IQ method in normal patients identified by DeXA. Three datasets of radiomics features were used, categorized based on their dimension (2D, 3D, projection map)Results: Our results indicate that best from AutoML process...
To survey the safety and efficacy of percutaneous cryoablation for renal tumors under local anesthesia pain control by using -40°C lethal isotherm ice ball to cover tumor margin as well coaxial technique.All procedures were performed between February 2014 November 2021 with computed tomography (CT) guidance. All ablated following aforementioned plan, according which margins covered isotherm. Hydrodissection in some cases avoid organ injury massive bleeding. 2% xylocaine was used 50 mg...
Our study aimed to compare bone scintigraphy and dual-layer detector spectral CT (DLCT) with multiphase contrast enhancement for the diagnosis of osteoblastic lesions in patients prostate cancer. The cancer detected on DLCT were divided into positive group (pBS) negative (nBS) based scintigraphy. A total 106 (57 nBS 49 pBS) was included. parameters each lesion measured from including Hounsfield unit (HU), 40-140 keV monochromatic HU, effective nuclear numbers (Zeff), Iodine no water (InW)...
Motivation: Kidney cancer is often diagnosed as either clear cell renal carcinoma (ccRCC) or non-clear (non-ccRCC) to determine treatment recommendations. Additionally, many patients with kidney cannot receive contrast medium due function disorders. Goal(s): for the distinction of ccRCC from other types RCC without administrationApproach: A model using automated machine learning (AutoML) based on radiomics features Results: Our results indicate that best AutoML process demonstrated a mean...
Based on the practical characteristics of basic course electronic technology, a new method optimizing circuit by using parameters scanning function PSpice simulation technology is proposed, which to perform transient meet functions amplifying circuit. After discovering unreasonable technical parameters, are scanned and modified. correcting incorrect optimized analyze design module used optimize design. The optimal process results voltage-divided bias amplifier this presented. experimental...
Abstract Purpose Many studies have shown that multiparametric magnetic resonance imaging (MRI) may be helpful for differentiating malignant renal cell carcinomas (RCCs) from benign lesions. However, the key characteristics differ between and tumors still require further discussion. Methods We analyzed 60 adult patients diagnosed with 72 small masses (SRMs) who received preoperative MRI 2014 to 2019 at a hospital in Taiwan. The features included conventional parameters, diffusion-weighted...