A5001269205- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Vector-Borne Animal Diseases
- Parasitic Infections and Diagnostics
- Animal Diversity and Health Studies
- Helminth infection and control
- Virology and Viral Diseases
- Natural Antidiabetic Agents Studies
- Glycosylation and Glycoproteins Research
- Clostridium difficile and Clostridium perfringens research
- Toxin Mechanisms and Immunotoxins
- Pesticide Exposure and Toxicity
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Vitamin C and Antioxidants Research
- Viral Infections and Vectors
- Livestock and Poultry Management
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Drug-Induced Hepatotoxicity and Protection
- Biochemical Acid Research Studies
- Pharmacological Effects of Natural Compounds
- Erythrocyte Function and Pathophysiology
Ahmadu Bello University
2014-2024
Federal University of Agriculture
2023-2024
Nigerian Institute of Medical Research
2006
Kansas State University
1979
Aim and Objectives: The world-threatening increases of types 1 2 diabetes mellitus their pressure on insulin other drugs led to the continued search for non-conventional as remedy particularly in countries with reduced economic growth. Therefore, traditional use Tithonia diversifolia leaves an antidiabetic medicinal plant was investigated its documentation into a data bank further technological development enhancement capacities meet challenges animal human population. Design Methods:...
The study evaluated the ameliorative effect of vitamin C on chronic chlorpyrifos-induced hematological alterations in Wistar rats. Twenty adult male rats divided into 4 groups 5 animals each were exposed to following regimens: group I (S/oil) was administered soya oil (2 mL/kg b.w.), while II (VC) given (100 mg/kg b.w.); III dosed with CPF (10.6 IV pretreated mg/kg) and then 30 minutes later. regimens by oral gavage once daily for a period 17 weeks. Blood samples collected at end revealed...
Objectives: Anogeissus leiocarpus stem bark is endowed with numerous antidiabetic properties, such as its prognostic value, treatment of organic damages, dyslipidaemia and enhancement haematopoiesis. In addition to antioxidant activity on oxidative stress, it accelerated wound healing has a wide range safety value. From the purification compounds points crystallization became necessary analyse structures for an insight into mechanisms actions.
 Design: Ethanolic extracts were...
An aqueous extract of defatted leaves Azadirachta indica was found to possess trypanocidal activity against Trypanosoma brucei brucei. Column chromatography the crude gave three fractions, I, II, and III, that eluted with ethylacetate/methanol, benzene/methanol, acetic acid/methanol, respectively. Of these extracts, only fraction III retained properties cured mice chronically infected Histopathological studies brains, livers, hearts, spleens treated showed no cellular infiltrations. These...
Objectives: The study aimed to identify the antidiabetic compounds purified from stem bark of Anogeissus leiocarpus and propose mechanisms action. Design: was through ethyl acetate n-hexane with minor exceptions. For very clear separation, cold acetone added trigger precipitation. precipitate dissolved a mixture DCM:methanol (9:1), adsorbed it silica gel (5 g), evaporated free flowing powder fractionated over (50 g) realize 40 fractions. gummy fractions were ignored. light brown which...
Anti-diabetic effects of ethanolic extract stem bark Anogeissus leiocarpus were investigated in alloxan monohydrate-induced acute type 1 diabetes mellitus (TIDM) extending into chronicity and organic damages 12 adult Nigerian indigenous dogs assigned 4 groups 3 each, namely: non-diabetic controls (ND), diabetic untreated (DU), insulin-treated (DI) extract-treated (DE). All parameters analysed using standard procedures. Hyperglycaemia occurred the dogs; blood glucose significantly (P < 0.001)...
Trypanosoma vivax stock V953 lysates were observed to produce neuraminidase (sialidase EC 3.2.1.18) in vitro, which cleaved neuraminic (sialic) acid from the substrate fetuin. The activity was proportional number of trypanosomes lysates, with 0.44, 0.88, and 1.75 X 10(6) producing 1.4 +/- 0.06, 3.1 0.1, 6.7 0.1 micrograms sialic liberated, respectively. Equal numbers unlysed lysed produced approximately same amount enzyme. Trypanosome eluates stored at room temperature appeared have lost...
Objectives: The maximum purification of the extracts antidiabetic Anogeissus leiocarpus stem bark led to a quest for its lethal dose (LD50) and effects on pregnancy, gestation, pups (kitten) reproductive performance Wistar rats.
 Design: Extracts A. were subjected column thin layer chromatography until final purification.
 Five (5) each adult male female rats used study. revised limit test 2000mg/kg.bd.wt. was evaluate acute oral toxicity characteristics purified rats. monitored...