A5079184097- Gastroesophageal reflux and treatments
- Rheumatoid Arthritis Research and Therapies
- Cholesterol and Lipid Metabolism
- Systemic Lupus Erythematosus Research
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Anesthesia and Sedative Agents
- bioluminescence and chemiluminescence research
- Retinoids in leukemia and cellular processes
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders Research
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Gallbladder and Bile Duct Disorders
- Inflammatory Bowel Disease
Sun Yat-sen University
2021-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2024
Sichuan University
2018-2020
Proton pump inhibitors (PPIs) have a major impact on gut microbiome and immune function, which in turn, may increase the risk of inflammatory bowel disease (IBD). Our aim this study was to evaluate PPI use subsequent IBD subtypes (ie, Crohn's ulcerative colitis).This pooled analysis Nurses' Health Study (NHS, n = 82,869), NHS II (n 95,141), UK Biobank 469,397). We included participants with information personal PPIs free or cancer at baseline. evaluated hazard ratios 95% confidence intervals...
Little is known on the gender-specific effect and potential role of non-linear associations between metabolic syndrome (MetS) components liver cancer risk. We evaluated these based UK Biobank cohort.We included 474,929 individuals without previous cohort. Gender-specific hazard ratios (HRs) 95% confidence interval (CIs) were calculated by Cox proportional hazards regression, adjusting for confounders. Non-linear individual MetS assessed restricted cubic spline method.Over a median follow-up...
Abstract Dementia is a well‐known syndrome and Alzheimer's disease (AD) the main cause of dementia. Lipids play key role in pathogenesis AD, however, prediction value serum lipidomics on AD remains unclear. This study aims to construct lipid score system predict risk progression from mild cognitive impairment (MCI) AD. First, we used least absolute shrinkage selection operator (LASSO) Cox regression model select lipids that can signify MCI based 310 older adults with MCI. Then constructed 14...
Abstract Several observational studies have suggested that proton‐pump inhibitor (PPI) use might increase diabetes risk, but the mechanism remains unclear. This study aimed to investigate effects of PPI on gut microbiota and bile acids (BAs) profiles, explore whether these changes could mediate association PPIs with fasting blood glucose (FBG) levels insulin resistance (IR) in Chinese population. A cross‐sectional was conducted Shenzhen, China, from April August 2021, enrolled 200 eligible...
The present study was conducted to assess the effect of all-trans retinoic acid (ATRA) on synovial explants from rats with rheumatoid arthritis (RA) induced by lipopolysaccharides (LPS). In our study, membranes were excised knees healthy adult Wistar female under sterile conditions. We first investigated synoviums incubated in a control medium or containing 10 μg/mL LPS, each for 24, 48, and 72 h (LPS-experiment). changes inflammatory response observed at different culture times. Then, we...
Recent epidemiological studies suggested that proton pump inhibitor (PPI) use was associated with an increased risk of biliary tract cancer (BTC), however, confounders were not adequately controlled. Our study aimed to evaluate PPI and subsequent BTC its subtypes in three well-established cohorts. We conducted a pooled analysis the subjects free cancers UK Biobank (n = 463 643), Nurses' Health Study (NHS, n 80 235) NHS II 95 869). Propensity score weighted Cox models used estimate marginal...
Abstract Background For patients taking esophagogastroduodenoscopy (EGD), sedation should ideally be used individually based on patients’ comfort and tolerance level. However, currently there is no valid predictive tool. We undertook this study to develop temporally validate a self-assessment tool for predicting discomfort in Chinese undergoing EGD. Methods recruited 1522 routine diagnostic EGD without sedation. collected candidate predictor variables before endoscopy evaluated with 5-point...
Current studies focused on the effects of all-trans-retinoic acid (ATRA) synovial explants from rats with rheumatoid arthritis (RA) induced by lipopolysaccharides (LPS). In our study, membranes were extracted aseptically quadriceps femoris knee joint rats, and then incubated in medium containing 10% neonate bovine serum for 24 h adaptive culture. We first measured variations correlation factors synovium at 24, 48, 72, 96 120 control or 20 ng/mL tumor necrosis factor alpha (TNF-α)...