A5071350112- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Congenital Anomalies and Fetal Surgery
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- Clostridium difficile and Clostridium perfringens research
- Advanced Thermodynamic Systems and Engines
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- COVID-19 Pandemic Impacts
- COVID-19 diagnosis using AI
- Bacteriophages and microbial interactions
- Viral Infections and Vectors
- Biosensors and Analytical Detection
- Animal Disease Management and Epidemiology
- COVID-19 and Mental Health
- Gut microbiota and health
- Plant Virus Research Studies
Scripps Research Institute
2018-2025
Thermo Fisher Scientific (Canada)
2024
Rega Institute for Medical Research
2010-2023
KU Leuven
2009-2023
Scripps (United States)
2021-2023
Scripps Institution of Oceanography
2021-2023
University of California, San Diego
2020-2023
Harvard University
2022
Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires
2021
Photometrics (United States)
2020
Abstract A major limitation for better understanding the role of human gut virome in health and disease is lack validated methods that allow high throughput analysis. To overcome this, we evaluated quantitative effect homogenisation, centrifugation, filtration, chloroform treatment random amplification on a mock-virome (containing nine highly diverse viruses) bacterial mock-community four faecal species) using PCR next-generation sequencing. This resulted an optimised protocol was able to...
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology SARS-CoV-2 Northern from late January to mid-March 2020, using samples 36 patients spanning nine counties and Grand Princess cruise ship. Phylogenetic analyses revealed cryptic introduction at least seven different lineages into California, including epidemic WA1 strains...
Rotaviruses (RVs) are responsible for more than 600,000 child deaths each year. The worldwide introduction of two life oral vaccines RotaTeq and Rotarix is believed to reduce this number significantly. Before the licensing both vaccines, new genotypes, G9 G12, emerged in human population were able spread across entire globe a very short time span. To quantify VP7 mutation rates these G12 genotypes estimate their most recent common ancestors, we used Bayesian Markov chain Monte Carlo...
Understanding the circumstances that lead to pandemics is important for their prevention. We analyzed genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in disease 2019 (COVID-19) pandemic. show SARS-CoV-2 before February 2020 likely comprised only two distinct viral lineages, denoted "A" and "B." Phylodynamic rooting methods, coupled with epidemic simulations, reveal these lineages were result at least separate cross-species transmission events into...
Summary As of January 2021, the highly transmissible B.1.1.7 variant SARS-CoV-2, which was first identified in United Kingdom (U.K.), has gained a strong foothold across world. Because sudden and rapid rise B.1.1.7, we investigated prevalence growth dynamics this States (U.S.), tracking it back to its early emergence onward local transmission. We found that RT-qPCR testing anomaly S gene target failure (SGTF), observed U.K., reliable proxy for detection. sequenced 212 SARS-CoV-2 genomes...
A limited number of human G6P[14] rotavirus strains that cause gastroenteritis in humans have been isolated Europe and Australia. The complete genome sequences were determined for five these strains--B10925-97 (isolated Belgium 1997), 111/05-27 (Italy, 2005), PA169 1987), MG6 (Australia, 1993), Hun5 (Hungary, 1997)--and their genetic relatedness to animal was evaluated by sequencing the sheep OVR762 (G8P[14]; Spain, 2002), guanaco (Lama guanicoe) Arg/Chubut/99 Arg/Río Negro/98 (G8P[14]...
Group A human rotaviruses (RVs) are a major cause of severe gastroenteritis in infants and young children. Yet, aside from the genes encoding serotype antigens (VP7; G-type VP4; P-type), little is known about genetic make-up emerging endemic RV strains. To gain insight into diversity evolution RVs circulating at single location over period time, we sequenced eleven-segmented, double-stranded RNA genomes fifty-one G3P[8] strains collected 1974 to 1991 Children's Hospital National Medical...
ABSTRACT Two live-attenuated rotavirus group A (RVA) vaccines, Rotarix (G1P[8]) and RotaTeq (G1-G4, P[8]), have been successfully introduced in many countries worldwide, including Belgium. The parental RVA strains used to generate the vaccines were isolated more than 20 years ago France (G4 strain RotaTeq) United States (all other strains). At present, little is known about relationship between currently circulating human RVAs vaccine strains. In this study, we determined sequences for VP7...
<b>Objective</b> To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. <b>Design</b> Prospective case-control study. <b>Setting</b> Random sample 39 Belgian hospitals, February 2008 to June 2010. <b>Participants</b> 215 admitted hospital with gastroenteritis confirmed by polymerase chain reaction and 276 age matched controls. All were an eligible have received (that is, born after 1 October 2006 aged ≥14 weeks). <b>Main outcome measure</b> Vaccination status...
Disturbances in the primary colonization of infant gut can result lifelong consequences and have been associated with a range host conditions. Although early-life factors shown to affect microbiota development, our current understanding human early life remains limited. To gain more insights into unique dynamics this rapidly evolving ecosystem, we investigated over first year eight densely sampled infants (n = 303 total samples). evaluate maturation transition toward an adult configuration,...
Abstract The emergence of SARS-CoV-2 variants concern has prompted the need for near real-time genomic surveillance to inform public health interventions. In response this need, global scientific community, through unprecedented effort, sequenced and shared over 10 million genomes GISAID, as May 2022. This extraordinarily high sampling rate provides a unique opportunity track evolution virus in real-time. Here, we present outbreak.info , platform that currently tracks 40 combinations PANGO...
Abstract Lassa fever is a severe viral hemorrhagic caused by zoonotic virus that repeatedly spills over to humans from its rodent reservoirs. It currently not known how climate and land use changes could affect the endemic area of this virus, limited parts West Africa. By exploring environmental data associated with occurrence using ecological niche modelling, we show temperature, precipitation presence pastures determine suitability for circulation. Based on projections climate, use,...
SignificanceMicrobes colonizing the infant gut during first year(s) of life play an important role in immune system development. We show that after birth (nearly) sterile is rapidly colonized by bacteria and their viruses (phages), which often a strong cooccurrence. Most infecting do not cause clinical signs numbers strongly increase day-care entrance. The diet clearly reflected identification plant-infecting viruses, whereas fungi parasites are part stable microbiota. These temporal...
Schools are high-risk settings for SARS-CoV-2 transmission, but necessary children's educational and social-emotional wellbeing. Previous research suggests that wastewater monitoring can detect infections in controlled residential with high levels of accuracy. However, its effective accuracy, cost, feasibility non-residential community is unknown.The objective this study was to determine the effectiveness accuracy community-based passive surface (environmental) surveillance infection...
G11 rotaviruses are believed to be of porcine origin. However, a limited number have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships these strains, we analyzed complete genomes 2 human G11P[25] G11P[8] 3 reference strains. Most 11 gene segments 7 strains belonged genotype 1 (Wa-like). phylogenetic clustering patterns suggested that an unknown strain new I12 VP6 was transmitted population, which it acquired...
There have been many reports of cyberintrusions, hacking, unauthorized operations, and malicious attacks on the electric power system. Many these are uncorroborated strengthen skepticism very people in position to prevent invasions. One vulnerability that has drawn substantial discussion is Aurora vulnerability, which focuses generators. Since dramatic video interview television news 2007 showing how cause severe damage a generator, generation providers concerned they could become victim....
Porcine epidemic diarrhea virus (PEDV) is a member of the family Coronaviridae and can cause severe outbreaks in piglets from different age groups. Here, we report complete genome sequence (28,028 nt) PEDV strain isolated during novel outbreak Belgium.
Abstract Animal host–microbe interactions are a relevant concern for wildlife conservation, particularly regarding generalist pathogens, where domestic host species can play role in the transmission of infectious agents, such as viruses, to wild animals. Knowledge on viral circulation is still scarce and be improved by recent advent modern molecular approaches. We aimed characterize fecal virome identify viruses potential conservation relevance diarrheic free‐ranging wolves sympatric dogs...