A5057143207- CAR-T cell therapy research
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Viral Infectious Diseases and Gene Expression in Insects
- S100 Proteins and Annexins
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- GDF15 and Related Biomarkers
- Immune Cell Function and Interaction
- Analytical Chemistry and Chromatography
Consejo Nacional de Investigaciones Científicas y Técnicas
2023-2024
University of Buenos Aires
2023-2024
We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. compared them with adenoviral (AdV), which are used in neuro-oncology, but there is pre-existing immunity. constructed BVs and AdVs encoding fluorescent reporter proteins evaluated their transduction efficiency glioma cells astrocytes. Naïve glioma-bearing mice were intracranially injected neuropathology. Transgene expression was also assessed BV-preimmunized mice. While weaker than murine human cell...
Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role pathogenesis cancer poorly understood. Here, we evaluated whether affects chemosensitivity glioblastoma (GBM) cells. We found that chemotherapy upregulated expression GBM lines and primary cultures derived from biopsies. An analog (HNGF6A) boosted chemoresistance, increased migration cells...
<title>Abstract</title> Purpose Glioblastoma (GBM) remains a formidable challenge in oncology due to its invasiveness and resistance treatment, i.e. surgery, radiotherapy, chemotherapy with temozolomide. This study aimed develop validate an integrated model predict the sensitivity of GBM alternative chemotherapeutics identify novel candidate drugs combinations for treatment GBM. Methods We utilized drug response data 272 compounds from CancerRxTissue, validated predictive model, therapeutic...
The regulatory T cell master transcription factor, Forkhead box P3 (Foxp3), has been detected in cancer cells; however, its role breast tumor pathogenesis remains controversial. Here we assessed Foxp3 intrinsic effects experimental using a binder peptide (P60) that impairs nuclear translocation. Cisplatin upregulated expression HER2+ and triple-negative (TNBC) cells. inhibition with P60 enhanced chemosensitivity reduced survival migration human murine We also developed an adenoviral vector...
Regulatory T cell master transcription factor, Forkhead box P3 (Foxp3) has been detected in cancer cells, but its role breast tumor pathogenesis remains controversial. Here we assessed Foxp3 intrinsic effects experimental using a binder peptide (P60) that impairs nuclear translocation. Cisplatin upregulated expression HER2+ and triple negative (TNBC) cells. inhibition with P60 enhanced chemosensitivity reduced survival migration human murine We also developed an adenoviral vector encoding...
ABSTRACT Purpose Glioblastoma (GBM) remains a formidable challenge in oncology due to its invasiveness and resistance treatment, i.e. surgery, radiotherapy, chemotherapy with temozolomide. This study aimed develop validate an integrated model predict the sensitivity of GBM alternative chemotherapeutics identify novel candidate drugs combinations for treatment GBM. Patients Methods We utilized drug response data 272 compounds from CancerRxTissue, validated predictive model, therapeutic...