A5088000082- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Cell death mechanisms and regulation
- RNA and protein synthesis mechanisms
- Insect Resistance and Genetics
- Fungal and yeast genetics research
- Glioma Diagnosis and Treatment
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Genetic Neurodegenerative Diseases
- S100 Proteins and Annexins
- Entomopathogenic Microorganisms in Pest Control
- CAR-T cell therapy research
- Virus-based gene therapy research
- Circular RNAs in diseases
- GDF15 and Related Biomarkers
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
Instituto de Biotecnología y Biología Molecular
2021-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2021-2024
Universidad Nacional de La Plata
2022-2023
We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. compared them with adenoviral (AdV), which are used in neuro-oncology, but there is pre-existing immunity. constructed BVs and AdVs encoding fluorescent reporter proteins evaluated their transduction efficiency glioma cells astrocytes. Naïve glioma-bearing mice were intracranially injected neuropathology. Transgene expression was also assessed BV-preimmunized mice. While weaker than murine human cell...
Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role pathogenesis cancer poorly understood. Here, we evaluated whether affects chemosensitivity glioblastoma (GBM) cells. We found that chemotherapy upregulated expression GBM lines and primary cultures derived from biopsies. An analog (HNGF6A) boosted chemoresistance, increased migration cells...
Tandem repeats (TRs) in protein sequences are consecutive, highly similar sequence motifs. Some types of TRs fold into structural units that pack together ensembles, forming either an (open) elongated domain or a (closed) propeller, where the last unit ensemble packs against first one. Here, we examine TR proteins (TRPs) to see how their sequence, structure, and evolutionary properties favor them for function as mediators interactions. Our observations suggest TRPs bind other using large,...
Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why improvement of technologies production recombinant baculoviruses takes on particular relevance. To achieve this goal, we developed highly versatile baculoviral transfer vector generation system called PluriBAC. The PluriBAC consists three insert entry levels using Golden Gate...
ABSTRACT Purpose The aim of the present work was to investigate role Receptor-interacting protein kinase 1 (RIPK1) both in mutated and wild type isocitrate dehydrogenase (IDH) Diffuse Gliomas (DG). Patients Methods We analyzed RIPK1 mRNA expression DG databases from Cancer Genome Atlas (TCGA) containing clinical, genomic transcriptomic information 661 patients. Transcriptomic studies (mRNA levels, correlation heatmaps, survival plots Gene Ontology meta-analysis immune gene signatures) were...
PURPOSE The aim of the present work was to investigate role apoptosis inhibitor BIRC6 (baculoviral IAP repeat-containing protein 6) in breast cancer (BC), focusing particularly on its involvement metastatic cascade. METHODS We analyzed mRNA expression levels and copy number variations three BC databases from Cancer Genome Atlas comparing clinical molecular attributes. Genomic analysis performed using cBioPortal platform, whereas transcriptomic studies (mRNA levels, correlation heatmaps,...
Abstract Breast cancer is the most common as well first cause of death by in women worldwide. BIRC6 (baculoviral IAP repeat-containing protein 6) a member inhibitors apoptosis family thought to play an important role progression or chemoresistance many cancers. The aim present work was investigate inhibitor breast cancer, focusing particularly on its involvement metastatic cascade. We analyzed mRNA expression levels and Copy Number Variations (CNV) three databases from Cancer Genome Atlas...