A5081880748- GDF15 and Related Biomarkers
- Growth Hormone and Insulin-like Growth Factors
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Nutrition and Health in Aging
- Estrogen and related hormone effects
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cell death mechanisms and regulation
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- CAR-T cell therapy research
- Apelin-related biomedical research
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- Chemokine receptors and signaling
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Neuroendocrine Tumor Research Advances
National University of Quilmes
2018-2024
University of Buenos Aires
2014-2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2021
Institute of Astronomy and Space Physics
2017
Abstract Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although shown to protect normal tissues from chemotherapy, its role tumor pathogenesis poorly understood. Here, we evaluated the on progression experimental triple negative breast cancer (TNBC). The meta-analysis transcriptomic data Cancer Genome Atlas indicated that and receptors are expressed...
Abstract Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- middle-income countries. Despite multiple efforts repurpose β-blocker propranolol oncology, its potential application osteosarcoma management remains largely unexplored. Considering the unsatisfied clinical needs of this aggressive disease, we evaluated antitumoral activity using different vitro vivo preclinical models, alone or addition...
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), homologous of HN expressed adult rat tissues, also has antiapoptotic action. In the present work, we demonstrated by immunocytochemical analysis flow cytometry expression HNr anterior pituitary female male rats well tumor GH3 was localized lactotropes somatotropes. The lower females than males, inhibited estrogens cells from both ovariectomized...
Abstract CK2 is a serine/threonine kinase that overexpressed in breast cancer and its inhibition associated to reduced tumor growth disease progression. CIGB-300 an antitumor peptide with novel mechanism of action, since it binds protein catalytic subunit alpha substrates thus preventing the enzyme activity. Our aim was evaluate potential therapeutic benefits on using experimental models translational relevance. We demonstrated reduces cell MDA-MB-231, MCF-7 F3II cells, exerting...
Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, correct balance pro- anti-apoptotic factors crucial for folliculogenesis. follicular atresia, survival or death of granulosa cells critical process. The goal this study was evaluate action HN on fate. To explore endogenous function we used recombinant baculovirus (BV) encoding...
e15087 Background: Desmopressin (dDAVP) is a hemostatic drug that acts as an agonist of the arginine vasopressin receptor 2 (AVPR2) present in vascular and malignant cells. Preclinical data show dDAVP triggers cytostatic mechanisms, blocking angiogenesis reducing metastases by limiting survival circulating tumor Triple-negative breast cancer (TNBC) associated with poor prognosis due to limited response therapy frequent early metastatic recurrence. Considering unsatisfied clinical need for...
Activation of nuclear factor (NF)-κB promotes cell proliferation and inhibits apoptosis. We have previously shown that oestrogens sensitise normal anterior pituitary cells to the apoptotic effect tumour necrosis (TNF)-α by inhibiting NF-κB translocation. In present study, we examined whether also modulate signalling pathway apoptosis in GH3 cells, a rat somatolactotroph line. As determined Western blotting, 17β-oestradiol (E2 ) (10(-9) m) increased concentration NF-κB/p105, p65 p50 cells....
Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE-inhibitory-protein) isoforms are regulatory proteins of apoptosis triggered by death receptors. c-FLIPshort isoform competes with procaspase-8 inhibiting its activation. However, c-FLIPlong may pro- or anti-apoptotic function depending expression level. In the present study, we...
La humanina es un péptido derivado de la mitocondria con efectos protectores robustos contra una gran variedad estímulos citotóxicos en diversos tipos celulares. Esto convierte blanco terapéutico interesante para muchas enfermedades, como el cáncer y enfermedades neurodegenerativas, entre otras. Además, este podría utilizarse biomarcador estas enfermedades. Durante última década, han sido desarrollados análogos péptido-miméticos que muestran resultados prometedores modelos preclínicos. A su...
Abstract The mitogen activated protein kinase (MAPK) p38 is a involved in the response to different external stimuli, extremely diverse such as oxidative stress or growth factors. Its activation triggers responses which include from promoting cell apoptosis cycle arrest, differentiation and of survival pathways. Although role cancer well studied field, there are still multiple unanswered questions, given large amount evidence supporting both tumorigenic but also tumor suppressor function for...
Abstract Humanin (HN) is a mitochondrial-derived peptide with potent cytoprotective effect in many cell types. Administration of HN has been proposed as therapeutic approach for several chronic diseases, such diabetes, neurodegenerative conditions and cardiovascular diseases. Although shown to protect normal tissues against the toxic effects chemotherapy, its role tumor chemoresistance poorly understood. Here, we aimed elucidate progression cytotoxic response experimental triple negative...
PURPOSE The aim of the present work was to investigate role apoptosis inhibitor BIRC6 (baculoviral IAP repeat-containing protein 6) in breast cancer (BC), focusing particularly on its involvement metastatic cascade. METHODS We analyzed mRNA expression levels and copy number variations three BC databases from Cancer Genome Atlas comparing clinical molecular attributes. Genomic analysis performed using cBioPortal platform, whereas transcriptomic studies (mRNA levels, correlation heatmaps,...
Abstract Our previous results indicate that systemic administration of a cell penetrating peptide (P60) inhibits Foxp3, transcription factor required for Treg function, improves the efficacy antitumor vaccines in experimental breast cancer. We also found P60 exerts direct effects, inhibiting tumor progression Foxp3+ tumors. Although there is controversy over role Foxp3 cells, we survival, proliferation and release IL-10 cells. Here aimed to evaluate pathways control expression murine LM3...
Abstract Breast cancer is the first cause of death from female cancer. After treatments against primary tumor, a few cells can prevail in state quiescence for long period time, becoming minimal residual disease. There clear need alternative techniques to enable an early detection disease better understanding it and generation therapies capable acting with smaller tumor burden. Although many models have been developed macrometastasis, there limitation vivo that allow identification...
Abstract CK2 is a serine-threonine kinase that has been involved in growth, proliferation and cell apoptosis. constitutive expression it more than 300 substrates. In recent years, became an interesting target for anticancer therapies. Inhibition of showed antitumor activity different types cancer. Because breast cancer one the main tumor which overexpressed, we focus on effect inhibition as modulator key features biology. The aim present study was to evaluate role by CIGB-300 murine human...