A5087383117- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Microbial infections and disease research
- Drug Transport and Resistance Mechanisms
- Aquaculture disease management and microbiota
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Animal Nutrition and Physiology
- Polysaccharides and Plant Cell Walls
- Immune Response and Inflammation
- Fungal Biology and Applications
- Quinazolinone synthesis and applications
- Aquaculture Nutrition and Growth
- Phenothiazines and Benzothiazines Synthesis and Activities
- Long-Term Effects of COVID-19
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- interferon and immune responses
- Animal Virus Infections Studies
- Plant-Microbe Interactions and Immunity
- Medicinal plant effects and applications
- Rabies epidemiology and control
- COVID-19 and Mental Health
- Polysaccharides Composition and Applications
Jimma University
2022
Kyungpook National University
2008-2012
A 28-d experiment evaluated the growth performance, acute-phase response, and bacterial shedding patterns in pigs (n = 108; initially, 38.7 ± 6.7 kg) fed 6 treatment diets, including a control diet with no antimicrobial agents (CON), positive containing chlortetracycline, 100 mg/kg (CT), anti-Salmonella Typhimurium bacteriophage, 3 × 10(9) plaque-forming units/kg of feed (ASB), Lactobacillus plantarum CJLP56, 6.5 10(8) cfu/kg (LP), 0.2% microencapsulated organic acids (MOA), or 5% fermented...
Although various biological activities of Phellinus gilvus (PG) have been reported, the active compounds responsible for these effects are not known. Here, we evaluated activity solvent extracts PG, and found ethyl acetate extract (Fd) to be most fraction, showing a strong DPPH free radical scavenging activity, inhibitory on LPS-induced nitric oxide (NO) production COX-2 mRNA expression in RAW264.7 macrophages. Six major were identified from protocatechualdehyde (PCA) was supposed phenolic...
The antibacterial activity and selection of resistant bacteria, along with mechanisms fluoroquinolone resistance, were investigated by integrating the static [MIC or mutant-prevention concentration (MPC)] in vitro dynamic model approaches using Escherichia coli isolates from diseased dogs. Using models, selected E. strains enrofloxacin marbofloxacin at a range simulated area under concentration-time curve over 24 h interval (AUC(24 h))/MIC ratios investigated. Our results indicated...
To investigate the mechanism by which Mycoplasma hyopneumoniae induces inflammatory responses in murine alveolar macrophage (MH-S) cells.A pathogenic strain of M. cultured modified Friis medium was used to response MH-S cell lines. The effect stimulation on production nitric oxide (NO) and cytokines cells inhibition their production, using specific inhibitors signalling pathways, investigated Griess reaction ELISA respectively. A Western blot assay confirm activation nuclear factor kappa B...
Clinical pharmacokinetic profiles were investigated following intramuscular (i.m.) administration to pigs with a commercial tylosin-florfenicol combination product at dose of 2.5 mg/kg tylosin and 5 florfenicol or 10 20 florfenicol. The quantitation limit (QL) was 0.1 μg/ml, the inter-day intra-day precision (CV%) both beow 10%. 0.05 μg/mL. characteristics after i.m. doses fitted by one compartment open model. A fourfold decrease in normal each drug (20 for florfenicol, tylosin) resulted...
The in vitro activity of 15 antimicrobial agents against clinical isolates Staphylococcus pseudintermedius, aureus, Escherichia coli, Pasteurella spp. and Streptococcus canis from dogs was investigated. For spp., the highest frequency resistance observed for penicillin, followed by ampicillin, tetracycline chloramphenicol. E. coli recorded streptomycin. S. had rate Most showed full susceptibility to low-level colistin, florfenicol fluoroquinolones. Further studies using larger number both...
ABSTRACT The pharmacokinetics (PK) and pharmacodynamics (PD) of orbifloxacin were studied in beagle dogs after intravenous (i.v.) intramuscular (i.m.) administration at a dose 2.5 mg/kg body weight. An absolute bioavailability 100.1% ± 4.76%, terminal half-life 4.23 0.2 h 3.95 0.15 i.v. i.m. administration, steady-state volume distribution 1.61 0.13 liters/kg, clearance 0.31 0.03 liters/h/kg observed. Orbifloxacin showed rapid, concentration-dependent killing against the Escherichia coli ,...
A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses 10 mg/kg (florfenicol) 5 (tylosin). Serum drug concentrations were determined by validated high performance liquid chromatography (HPLC) using UV detection. rapid nearly complete absorption both drugs with mean IM bioavailability 103.9% 92.6% (tylosin), prolonged elimination half-life, tissue penetration...
The objective of this study was to analyze the relationship between pharmacokinetic parameters and body weight (W) for orbifloxacin using reported data. interest: clearance (Cl), volume distribution at steady state (Vss) elimination half-life were correlated across nine mammal species, including cattle, dog, rat, rabbit, goat, camel, horse, cat sheep as a function W conventional allometric equation Y = aWb, where is parameter, weight, coefficient (intercept) b exponent that describes...
Subacute toxicity and immunopharmacological activities of β-glucan from P. polymyxa JB115 was evaluated in a 28-day feeding study rats. The white blood cell count, red hematocrit, hemoglobin, thrombocytes (THR) thrombocytocrit were significantly higher male fed with than control rats the insignificant lower eosinophil mean corpuscular volume, hemoglobin uninfected THR (uTHR) levels observed whereas no marked changes female No other significant differences serum chemistry liver, kidney,...
COVID-19 has been a sudden public health crisis since January 2020, spreading from the city of Wuhan, China, to whole country within month and posing serious threats lives. The pandemic profound effect on all aspects society, including mental physical health. actual virus brain possible psychiatric manifestations is still an area study further investigation. There are also several case reports showing manic like symptoms after infection. We describe 55-year-old patient who presented with...