A5070504413- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Vestibular and auditory disorders
- Respiratory Support and Mechanisms
The University of Melbourne
2020-2023
Abstract Study Objectives Genioglossus (GG) after-discharge is thought to protect against pharyngeal collapse by minimizing periods of low upper airway muscle activity. How GG occurs and which single motor units (SMUs) are responsible for the phenomenon unknown. The aim this study was investigate genioglossal after-discharge. Methods During wakefulness, elicited 8–12 times in healthy individuals with brief isocapnic hypoxia (45–60 s 10% O2 N2) terminated a breath 100% O2. SMUs were...
Transient arousal from sleep has been shown to elicit a prolonged increase in genioglossus muscle activity that persists following the return and which may protect against subsequent airway collapse. We hypothesized this increased genioglossal after an is due persistent firing of inspiratory-modulated motor units (MUs) are recruited during arousal. Thirty-four healthy participants were studied overnight while wearing nasal mask with pneumotachograph measure ventilation 4 intramuscular EMG...