Aim: This study aimed to investigate post‐marketing adverse events (AEs) of interleukin‐6 (IL‐6) inhibitors, and explore risk factors for death. Method: Disproportionality analyses were conducted on event cases IL‐6 inhibitors reported the US Food Drug Administration Adverse Event Reporting System (FAERS) from time drug launch until fourth quarter 2023. Univariate multivariate logistic regression carried out utilizing patient‐related clinical information, prediction models inhibitor‐related...

SignificanceHepatocyte spheroids (HCSs) are three-dimensional (3D) in vitro models that exhibit a multilayered structure with site-dependent cell viability. The non-invasive identification of HCS and viability variation is essential fully exploiting the potential as model for liver disease research.AimWe aim to achieve long-term, monitoring quantification based on dynamic optical coherence tomography (D-OCT) enhance visualization internal activity D-OCT pseudo-color images.ApproachWe...

Summary Rural social work is instrumental in addressing grassroots issues and fostering rural community development, an understanding of network structure can enhance service efficiency quality. The research explores the effectiveness by employing analysis within project “Seven Colors Light” Village M, County A, China. study analyzes interaction patterns among government agencies, professional workers, other stakeholders, emphasizing need for structures to delivery Findings findings...

Reconstructing and quantitatively assessing the internal architecture of opaque three-dimensional (3D) bioprinted hydrogel scaffolds is difficult but vital to improvement 3D bioprinting techniques fabrication functional engineered tissues. In this study, swept-source optical coherence tomography was applied acquire high-resolution images scaffolds. Novel gelatin/alginate with six different representative architectures were fabricated using our system. Both scaffold material networks...

Organoids are advancing the development of accurate prediction drug efficacy and toxicity in vitro. These advancements attributed to ability organoids recapitulate key structural functional features organs parent tumor. Specifically, self-organized assembly with a multi-scale structure 30-800 μm, which exacerbates difficulty non-destructive three-dimensional (3D) imaging, tracking classification analysis for organoid clusters by traditional microscopy techniques. Here, we devise 3D...

Extrusion-based three-dimensional (3D) bioprinting is one of the most common methods used for tissue fabrication and widely additive manufacturing technique in all industries. In extrusion-based bioprinting, printing defects related to material deposition errors lead a significant deviation from shape function between printed construct design model. Using 3D bioprinter-associated optical coherence tomography (3D P-OCT), an

Background The treatment options for cognitive impairments in Parkinson’s disease (PD) are limited. Repetitive transcranial magnetic stimulation has been applied various neurological diseases. However, the effect of intermittent theta-burst (iTBS) as a more developed repetitive paradigm on dysfunction PD remains largely unclear. Objective Our aim was to explore acute iTBS hippocampus-dependent memory and mechanism underlying it. Methods Different blocks protocols were unilateral...

Patient-derived organoids (PDOs) serve as excellent tools for personalized drug screening to predict clinical outcomes of cancer treatment. However, current methods efficient quantification response are limited. Herein, we develop a method label-free, continuous tracking imaging and quantitative analysis efficacy using PDOs. A self-developed optical coherence tomography (OCT) system was used monitor the morphological changes PDOs within 6 days administration. OCT image acquisition performed...

When optical coherence tomography (OCT) is used for human retina imaging, its transverse resolution limited by the aberrations of eyes. To overcome this disadvantage, a high imaging system living retina, which consists time domain OCT and 37-elements adaptive optics (AO) system, has been developed. The AO closed loop rate 20 frames per second, 6.7-μm axial resolution. In paper, introduced results are presented.

Incorporating different data processing methods, optical coherence tomography (OCT) has the ability for high-resolution angiography and quantitative flow velocity measurements. However, OCT cannot provide information of velocities, measurement based on Doppler requires determination angles, which is a challenge in complex vascular network. In this study, we report relative standard deviation (RSD-OCT) method provides both network mapping velocities within wide range angles. The RSD values...

Multicellular tumor spheroid (MCTSs) models have demonstrated increasing utility for in vitro study of cancer progression and drug discovery. These relatively simple avascular constructs mimic key aspects vivo tumors, such as 3D structure pathophysiological gradients. MCTSs can provide insights into cell behavior during development response to drugs; however, their requisite size drastically limits the tools used non-destructive assessment. Optical Coherence Tomography structural imaging...

Ultraviolet (UV) irradiation causes 90% of photodamage to skin and long-term exposure UV is the largest threat health. To study mechanism UV-induced repair sunburnt skin, key problem solve how non-destructively continuously evaluate skin. In this study, a method quantitatively analyze structural tissue optical parameters artificial (AS) using coherence tomography (OCT) was proposed as way effect photodamage. AS surface roughness achieved based on characteristic peaks intensity signal OCT...

A compact, fiber-based spectrometer for biomedical application utilizing a tilted fiber Bragg grating (TFBG) as integrated dispersive element is demonstrated. Based on 45° UV-written PS750 TFBG refractive with 2.06 radiant/μm dispersion and numerical aperture of 0.1 was set up tested detector an optical coherence tomography (OCT) system. Featuring 23 mm long active region at the spectrum projected via cylindrical lens vertical beam collimation focused by achromatic doublet onto array....

A tilted fiber Bragg grating (TFBG) was integrated as the dispersive element in a high performance biomedical imaging system. The spectrum emitted by 23 mm long active region of is projected through custom designed optics consisting cylindrical lens for vertical beam collimation and successively an achromatic doublet onto linear detector array. High resolution tomograms samples were successfully acquired frequency domain OCT-system. Tomograms ophthalmic dermal obtained OCT-system achieving...

Axial resolution and traverse in optical coherence tomography (OCT) imaging are determined by different factors, while axial is both the length of light source beam-focusing condition, condition sample arm. In main approaches to improvement OCT, a with broaden bandwidth used gating combined apodization, which cannot improve resolution. A method introduced increase simultaneously an OCT system path code coherent compounding method. Different effective functions formed adding coding lens...

This study aims to review and describe the national post-market cases of oral anticoagulants (OACs)-induced intracranial hemorrhage (ICH) enhance patient safety.

Significance: Artificial skin (AS) is widely used in dermatology, pharmacology, and toxicology, has great potential transplant medicine, burn wound care, chronic treatment. There a demand for high-quality AS product non-invasive detection method highly desirable. Aim: To quantify the constructure parameters (i.e., thickness surface roughness) of samples culture cycle explore growth regularities using optical coherent tomography (OCT). Approach: An adaptive interface algorithm developed to...