A5113359184- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Probiotics and Fermented Foods
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
Université de Montréal
2024
Montreal Heart Institute
2024
Abstract Antimicrobial resistance (AMR) is a global threat. To optimize the use of our antifungal arsenal, we need rapid detection and monitoring tools that rely on high-quality AMR mutation data. Here, performed thorough manual curation published mutations in fungal pathogens to produce FungAMR reference dataset. A total 462 papers were curated, leading 54,666 entries all classified with degree evidence supports their role resistance. covers 92 species, 202 genes 184 drugs. We combined...
Candida auris has emerged as a significant healthcare-associated pathogen due to its multidrug-resistant nature. Ongoing constraints in the discovery and provision of new antifungals create an urgent imperative design effective remedies this pressing global blight. Herein, we screened chemical library identified aryl-carbohydrazide analogs with potent activity against both C. most prevalent human fungal pathogen, albicans . SPB00525 [ N ’-(2,6-dichlorophenyl)-5-nitro-furan-2-carbohydrazide]...