A5100019767- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
Summary Changes in the genome wide DNA methylation landscape are hallmarks of cancer cells and precursor lesions cancers. To capitalize on utilizing for detection classification cancer, we generated a database gynecological cancers associated healthy tissues using Methylated sequencing (MeD-seq). We show that target cell enrichment to generate is crucial marker discovery report range novel biomarkers tissue origin determination developed subset these biomarkers, both intragenic intergenic,...
Abstract DNA damage tolerance (DDT) is an important pathway that allows our cells to bypass lesions during replication. DDT orchestrated by ubiquitination of PCNA: Monoubiquitination (PCNA-Ub) initiates recruitment TLS polymerases but also serves as substrate for K63-linked polyubiquitination leads HR-mediated mechanisms. Recent work on USP1/UAF1 inhibition revealed K48-linked chains are formed PCNA, resulting in its proteasomal degradation. established deubiquitinating enzyme (DUB) PCNA-Ub,...