A5070827889- Gut microbiota and health
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Microbial Community Ecology and Physiology
- Bacterial Infections and Vaccines
- Peptidase Inhibition and Analysis
- Complement system in diseases
University of Virginia
2022-2023
Neisseria gonorrhoeae infection is characterized by local and abundant recruitment of neutrophils. Despite neutrophils' antimicrobial activities, viable N. recovered from infected individuals, leading to the question how survives neutrophil attack. One feature impacting gonorrhoeae-neutrophil interactions phase-variable opacity-associated (Opa) proteins. Most Opa proteins engage human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) facilitate bacterial binding invasion....
ABSTRACT The ability of bacterial pathogens to metabolically adapt the environmental conditions their hosts is critical both colonization and invasive disease. Infection with Neisseria gonorrhoeae (the gonococcus, Gc) characterized by influx neutrophils [polymorphonuclear leukocytes (PMNs)], which fail clear bacteria make antimicrobial products that can exacerbate tissue damage. inability human host Gc infection particularly concerning in light emergence strains are resistant all clinically...
Abstract The ability of bacterial pathogens to metabolically adapt the environmental conditions their hosts is critical both colonization and invasive disease. Infection with Neisseria gonorrhoeae (the gonococcus, Gc) characterized by influx neutrophils (PMNs), which fail clear bacteria make antimicrobial products that can exacerbate tissue damage. inability human host Gc infection particularly concerning in light emergence strains are resistant all clinically recommended antibiotics....