Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder caused by the expansion of a CTG-triplet repeat in 3′ untranslated region dystrophia myotonica protein kinase ( DMPK ) gene. It results transcription toxic RNAs that contain expanded CUG repeats (CUG exp ). Splicing factors, such as muscleblind-like (MBNL1), are sequestered , thereby disrupting normal splicing program essential for various cellular functions. Pentatricopeptide (PPR) proteins, originally found...

Loss of the nucleus is a critical step in keratinocyte terminal differentiation. To elucidate mechanisms involved, we focused on two characteristic events: nuclear translocation N-terminal fragment profilaggrin and caspase-14-dependent degradation inhibitor caspase-activated DNase (ICAD). First, demonstrated that epidermal mesotrypsin liberated 55-kDa (FLG-N) FLG-N was translocated into nucleus. Interestingly, these cells became TUNEL positive. Mutation mesotrypsin-susceptible Arg-rich...

Background: Past studies have analyzed individual jobs in dyestuff factories, materials manufactured and handled, age at exposure, the duration of exposure factories as factors related to occurrence urothelial tumors. None these was based on long‐term observation, involved tumors remain controversial. In this study, various that may affect dye workers were assessed by multivariate analysis. Methods: Three hundred sixty‐three nine member Dyestuff Industrial Cooperative associated included...

Magnetic resonance imaging (MRI) visualization of metallic stent lumens is possible if the structure counteracts eddy currents in lumen induced by radio frequency magnetic field, B(1). To examine effectiveness various designs counteracting currents, we anchored eight copper models and 2 commercially available nickel-titanium alloy (Nitinol) stents a gel phantom, perpendicular or parallel to direction A mesh showed hypointensity irrespective its alignment relative solenoid with axis B(1), but...

In the dopamine transporter scintigraphy there are two quantitative analysis softwares, DaTView and DaTQUANT. The value of both software has to be treated independently because is a difference between them in point how set region interest on striatum background, calculation formula quantitation. And also DaTQUANT capability performing anatomical standardization which does not have. aim this study was evaluate accuracy registration using phantom, correlation values clinical data. As result,...

Purpose: This study aimed to verify the resolution recovery for each collimator in brain perfusion image. Method: To effect of collimator, we evaluated via three-dimensional phantom (phantom) and normal single photon emission computed tomography (SPECT) data. These data were reconstructed using ordered subset expectation maximization method (3D-OSEM) (Evolution boneTM) that was performed with scatter correction, attenuation (RR). The performance two systems (ELEGP MEGP) reconstruction...

The discovery of NM530c with a cadmium-zinc-telluride detector (CdZnTe-SPECT) is superior to the conventional Anger-type SPECT sodium-iodide (NaI-SPECT) in terms sensitivity and spatial resolution. However, clinical example, even CdZnTe-SPECT, count decrease myocardium due attenuation gamma ray an issue. This study was conducted evaluate effect computed tomography correction (CTAC) CdZnTe-SPECT help external CT. We evaluated revision uniformity, influence by difference distance, contrast...

<title>Abstract</title> Objective The aim of this study was to generate pseudo CT images for attenuation correction (AC) from non-AC SPECT and evaluate the accuracy deep learning-based AC in ^99mTc-labeled galactosyl human serum albumin (^99mTc-GSA) SPECT/CT hepatic imaging. Methods A cycle-consistent generative network (CycleGAN) used 40 patients with normal liver function. test cohort consisted one patient function abnormal were reconstructed without...

Osteosclerotic images are known as an image appearance of occult femoral neck fractures in X-ray images. The aim this study is to investigate frequency enhancement processing that improves the visibility osteosclerotic image.

Objective The aim of this study was to evaluate the effects single-photon emission computed tomography (SPECT) acquisition method and sampling angles on qualitative quantitative interpretations xSPECT-reconstructed images. Methods spatial resolution evaluated using a JSP phantom, uniformity accuracy were verified with NEMA IEC Body Phantom an SIEMENS Symbia Intevo SPECT/computed system. SPECT performed three methods (step-and-shoot, continuous, acquire during step), set 2, 3, 4, 5, 6°....

In proton density-weighted (PDW) MR imaging, the patterns of signal intensity vary depending on imaged material, and change with flip angle (FA) applied to material. The correlation between pre-determined FA actual objects was investigated using 4 types phantoms having different dielectric properties. PDW images were acquired spin-echo (SE) method FA. Dependency distribution in phantom differed among phantoms: for water 0.402 w/w% saline solution changed FA, whereas those olive oil 4.02...

We report on a case of prostatic cancer with multiple bone metastases, including right orbital involvement.Hormonal treatment and local irradiation to the orbit were performed. Subjective symptoms exophthalmos pain disappeared.We metastasizing bone.

Discovery NM 530c (CZT SPECT) is a new single photon emission computed tomography (SPECT) scanner using cadmium-zinc-telluride (CZT) solid-state semiconductor detector technology. Due to multi-pinhole collimator design of this system, each CZT facing different direction and be able get incidence radioactivity from radioisotopes (RIs) existing outside effective field view (EFOV). The purpose study verify its impact compare it conventional Anger-type SPECT (Discovery NM/CT 670 pro). We used...

To compare the isolating efficiency of diarrhea-causing Escherichia coli between Fluorocult agar plates, which reveal β-glucuronidase activity E. coli, and a combination SS DHL total 330 fecal specimens collected from outpatients were examined. Diarrhea-causing identified by serological toxigenic characters, demonstrated in 52 samples. Among these specimens, 35 samples tested positive on 26 plates. However, only 10 both plates Thus, using for isolation addition to conventional will improve efficacy.

P-694 Objectives: The Health Center in Minamata was notified of the first patient on May 1st, 1956. number victims serious matter, however, is still unknown. One reasons uncertainty Japanese criteria methyl-mercury poisoning settled 1977, which require combinations related signs. In order to examine validity current Criteria Methyl-mercury Patients, has been maintained by Government as “purely medical” since we analyzed original data largest and most detailed epidemiologic investigation...