A5103118586- Immune responses and vaccinations
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Biotin and Related Studies
- bioluminescence and chemiluminescence research
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
Children's Hospital of Philadelphia
2024
Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, identify nicotinamide adenine dinucleotide (NAD) biosynthesis as biochemical hub for T cell receptor affinity-dependent metabolome. Through central anabolic role, found NAD governs quiescence exit checkpoint, thereby...
Abstract Undernutrition is one of the largest persistent global health crises, with nearly 1 billion people facing severe food insecurity. Infectious disease represents main underlying cause morbidity and mortality for malnourished individuals, infection during malnutrition representing leading childhood worldwide. In face this complex challenge, simple refeeding protocols have remained primary treatment strategy. Although an association between undernutrition susceptibility has been...
Undernutrition is one of the largest persistent global health crises, with nearly 1 billion people facing severe food insecurity. Infectious disease represents main underlying cause morbidity and mortality for malnourished individuals, infection during malnutrition representing leading childhood worldwide. In face this complex challenge, simple refeeding protocols have remained primary treatment strategy. Although an association between undernutrition susceptibility has been appreciated over...
<p>The detection and quantification of nucleic acids over a range concentrations presents an analytical challenge. Thus, there is urgency to develop more sensitive technologies that can quantify specific acid sequences with lower limits than traditional methods. Amplification methods such as polymerase chain reaction (PCR) are often non-linear frequently make transition from undetectable saturated narrow concentration range. Biotinylation deoxynucleic (DNA) precondition for the...
<p>The detection and quantification of nucleic acids over a range concentrations presents an analytical challenge. Thus, there is urgency to develop more sensitive technologies that can quantify specific acid sequences with lower limits than traditional methods. Amplification methods such as polymerase chain reaction (PCR) are often non-linear frequently make transition from undetectable saturated narrow concentration range. Biotinylation deoxynucleic (DNA) precondition for the...
Undernutrition is one of the largest persistent global health crises, with nearly 1 billion people facing severe food insecurity. Infectious disease represents main underlying cause morbidity and mortality for malnourished individuals, infection during malnutrition representing leading childhood worldwide. In face this complex challenge, simple refeeding protocols have remained primary treatment strategy. Although an association between undernutrition susceptibility has been appreciated over...