A5103031646- Cellular transport and secretion
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Blood transfusion and management
- Cellular Mechanics and Interactions
- Salivary Gland Disorders and Functions
- Water Resource Management and Quality
- Calpain Protease Function and Regulation
- Erythropoietin and Anemia Treatment
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Antimicrobial Peptides and Activities
- Caveolin-1 and cellular processes
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Blood donation and transfusion practices
- Inflammasome and immune disorders
- Protein Kinase Regulation and GTPase Signaling
- Magnetic and Electromagnetic Effects
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Superconductivity in MgB2 and Alloys
- Kawasaki Disease and Coronary Complications
- Renal and related cancers
- Hemoglobinopathies and Related Disorders
San Sebastián University
2024
Austral University of Chile
2017-2024
University of Chile
1974-2022
University of Dental Medicine
2014
Faculty (United Kingdom)
2014
Pontificia Universidad Católica de Chile
1974
Migration and invasion are essential steps associated with tumor cell metastasis increasing evidence points towards endosome trafficking being in this process. Indeed, the small GTPase Rab5, a critical regulator of early dynamics, promotes migration vitro vivo. Precisely how Rab5 participates these events remains to be determined. Considering that focal adhesions represent structures crucial migration, we specifically asked whether activation promoted adhesion disassembly thereby facilitated...
Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion migration. Specifically, promotes Rac1 activation cancer migration, but little known about upstream regulators of Rab5. We have previously shown the scaffolding protein Caveolin-1 (CAV1) migration cells. Here, we hypothesized CAV1 stimulates activation, leading to increased activity Expression in B16-F10 mouse melanoma HT-29(US) human colon adenocarcinoma cells Rab5-GTP...
Saliva is a key factor that contributes to the high efficiency of wound healing in oral mucosa. This not only attributed physical cues but also presence specific peptides saliva, such as histatins. Histatin-1 38 aa antimicrobial peptide, highly enriched human which has been previously reported promote migration keratinocytes and fibroblasts vitro. However, participation histatin-1 other crucial events required for healing, angiogenesis, unknown. Here we demonstrate promotes shown vivo, using...
// Patricio Silva 1 , Pablo Mendoza Solange Rivas Jorge Díaz Carolina Moraga Andrew F.G. Quest 2, 3 Vicente A. Torres 1, 2 Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile Advanced Center Chronic Diseases (ACCDiS), Medicine, Molecular Studies the Cell (CEMC) and Program Biology, Biomedical Correspondence to: Torres, e-mail: vatorres@med.uchile.cl Keywords: Rab5, hypoxia, migration, metastasis, tumor Received: November 10,...
Diabetic nephropathy (DN) is considered the main cause of kidney disease in which myofibroblasts lead to renal fibrosis. Macrophages were recently identified as major source a process known macrophage–myofibroblast transition (MMT). Adenosine levels increase during DN and vivo administration MRS1754, an antagonist A2B adenosine receptor (A2BAR), attenuated glomerular fibrosis (glomerulosclerosis). We aimed investigate association between A2BAR MMT glomerulosclerosis DN. Kidneys/glomeruli...
Increased cell migration is an acquired feature of metastatic cancer cells and relies on derailed signal transduction pathways. Intracellular vesicular trafficking plays a key role in due to its intricate involvement cargo transport membrane composition. In the last decade, endocytosis has been implicated found be responsible for internalization receptors at plasma membrane, where integrin fine-tuning receptor tyrosine kinase signaling by are major mechanisms. Accumulating evidence suggested...
Induction of the adenosine receptor A
The early endosome protein Rab5 was recently shown to promote cell migration by enhancing focal adhesion disassembly through mechanisms that remain elusive. Focal is associated proteolysis of talin, in a process requires calpain2. Since calpain2 has been found at vesicles and endosomal compartments, we hypothesized stimulates activity, leading enhanced migrating cells. We observed co-localizes with EEA1-positive endosomes co-immunoprecipitates EEA1 A549 lung carcinoma cells undergoing...
Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive responses. Recent findings have reported that Ngo reduces IL-1β secretion of infected human monocyte-derived macrophages (MDM). Here, we investigate role adenosine triphosphate (ATP) in production release Ngo-infected MDM. We found exposure MDM to ATP increases levels about ten times compared with unexposed (P < 0.01). However, did not observe any changes inflammasome...
The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently implicated as a critical regulator cell adhesion, migration and invasion both normal tumor cells. These recent findings showing that promotes Rac1 activation focal adhesion dynamics have highlighted question to what upstream regulators activity might be how these are connected migration. efforts shed light on this issue identified metastatic cancer cells novel...
The monoamine oxidase (MAO) gene family encodes for enzymes that perform the oxidative deamination of monoamines, a process required to degrade norepinephrine, serotonin, dopamine, and other amines. While mammalian MAO enzymes, A B, have been extensively studied, molecular properties members are only partly uncovered. This study aims explore evolution oxidases, emphasizing understanding repertoire among vertebrates. Our analyses show duplication gave rise B occurred in ancestor tetrapods,...
Abstract The monoamine oxidase (MAO) gene family encodes for enzymes that perform the oxidative deamination of monoamines, a process required to degrade norepinephrine, serotonin, dopamine, and other amines. While mammalian MAO enzymes, A B, have been extensively studied, molecular properties members are only partly uncovered. This study aims explore evolution oxidases, emphasizing understanding repertoire among vertebrates. Our analyses show duplication gave rise B occurred in ancestor...
Gallbladder cancer (GBC) is a prevalent and deadly biliary tract carcinoma, often diagnosed at advanced stages with limited treatment options. The 5-year survival rate varies widely from 4 to 60%, mainly due differences in disease stage detection. With only small fraction of patients having resectable tumors high incidence metastasis, GBC are characterized by significant chemoresistance. Identification new therapeutic targets crucial, recent studies have shown that the Endothelin-1 (ET-1)...
When the derivative of spreading pressure with respect to adsorbed volume is obtained for adsorption isotherms nitrogen, oxygen, and carbon dioxide on ZnO between 75.6 208.8 K, a maximum found capacity monolayer.