A5093493468- Lysosomal Storage Disorders Research
- Gut microbiota and health
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Reproductive Health and Technologies
- Epigenetics and DNA Methylation
- Complement system in diseases
- Nitric Oxide and Endothelin Effects
- Genetic and Kidney Cyst Diseases
Universidade Federal do Paraná
2023-2024
Abstract Epigenetic analysis is a fundamental part of understanding pathophysiological processes with potential applications in diagnosis, prognosis, and assessment disease susceptibility. changes have been widely studied chronic obstructive pulmonary (COPD), but currently, there no molecular marker used to improve the treatment patients. Furthermore, this progressive risk factor for development more severe COVID-19. Methylation-specific polymerase chain reaction (MSP-PCR) plays an important...
Podocyte dysfunction plays a crucial role in renal injury and is identified as key contributor to proteinuria Fabry disease (FD), primarily impacting glomerular filtration function (GFF). The α3β1 integrins are important for podocyte adhesion the basement membrane, disturbances these can lead injury. Therefore, this study aimed assess effects of chloroquine (CQ) on podocytes, drug be used obtain an vitro condition analogous FD. Murine podocytes were employed our experiments. results revealed...