A5073084810- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Cancer Immunotherapy and Biomarkers
- Human Health and Disease
- Healthcare Systems and Public Health
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Endometrial and Cervical Cancer Treatments
- Biomarkers in Disease Mechanisms
- Adsorption, diffusion, and thermodynamic properties of materials
- Diet and metabolism studies
- Genetic factors in colorectal cancer
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Sodium Intake and Health
- Lipid metabolism and disorders
- Bladder and Urothelial Cancer Treatments
- BRCA gene mutations in cancer
- Infrared Thermography in Medicine
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
Avaya (Bermuda)
2024
National Scientific Center "M.D. Strazhesko Institute of Cardiology"
2016-2019
National Academy of Medical Sciences of Ukraine
2018
Kuban State University
2012
Aim . To assess the efficacy and safety of lenvatinib pembrolizumab for treatment mismatch repair-proficient endometrial cancer (EC) in routine clinical practice Russia. Materials methods This multicenter, retrospective, cohort study included patients with recurrent metastatic EC from 37 centers Russia treated between May 2020 April 2023. Patients histologically verified without microsatellite instability who received ≥1 course pembrolizumab/lenvatinib therapy were study. The primary...
In most cases, ovarian cancer is diagnosed at advanced stages, leading to a poor prognosis. Currently, there no effective screening for cancer, so detecting it in the early stages fairly successful case.
Background. Endometrial cancer (EC) treatment outcomes need to be improved. Immunotargeted therapy lead long-term and delayed effects compared chemotherapy. Estimation of efficacy quality life are crucial when we talking about in whole. Aim. To evaluate the clinical lenvatinib plus pembrolizumab patients with EC. Materials methods . The study included 43 stages I-IV EC mismatch repair-proficient tumors duration more than 9 months. We evaluated median progression-free survival, objective...
Цель исследования: Анализ публикаций о существующих методах сохранения фертильности у пациентов репродуктивного возраста, перед проведением гонадотоксичной противоопухолевой терапии. Материал и методы: Обзор статей, опубликованных в зарубежной отечественной литературе за последние 10 лет. Результаты: Проблема становится более актуальной с каждым годом. На сегодняшний день все чаще поднимается вопрос не только проведении наиболее эффективного лечения онкологических заболеваний, но последующем...
The aim – to study the activity of low-grade inflammation and determine an interaction its parameters with characteristics humoral systems blood pressure regulation, hypertensive heart kidney damage in patients resistant arterial hypertension (AH).Material methods. results examination 129 AH (72 controlled AH, 57 persons AH) were included into analysis. All patients, besides routine clinical examination, underwent 24-hours’ monitoring, evaluation systemiс markers (C-reactive protein,...
The aim – to study the effectiveness of spironolactone, eplerenone, nebivolol, moxonidine as 4th component therapy in patients with resistant arterial hypertension.Material and methods. involved 66 true hypertension (RAH). average age was 51.9±1.2 years, mostly men (59.1 %). In addition standard triple-dose fixed combination antihypertensive tharepy, all received turn spironolactone (45.0±3.6 mg/day), eplerenone (47.9±2.1 nebivolol (8.9±0.6 mg/day) (0.5±0.1 mg/day). After completion each...
Objective: To examine the additional to antihypertensive treatment effect of rosuvastatin on a left ventricular mass index (LVMI) and parameters low - grade systemic inflammation at high risk essential hypertensive patients. Design method: 43 statin naïve patients (EH pts) were included in study. All EH pts treats with fixed dose combination valsartan 160 mg amlodipine 5 mg. They randomized into two groups: 23 10 day 20 without any therapy. Baseline (after 1 week wash-out previous treatment)...
Objective: It is suggested that the development of resistant hypertension (RH) associated with hyperactivity renin-angiotensin-aldosterone system (RAAS) and sympathetic system. But precise mechanisms leading to resistance treatment have not established. Aim: To investigate relation RAAS activity low grade inflammation renal function in patients RH. Design method: The study included 51 essential In 21 RH was excluded they formed a control group. Plasma renin (PRA) aldosterone were estimated....
Objective: To investigate characteristics of circadian blood pressure rhythm, frequency and character hypertensive damage heart, kidney carotid arteries in patients (pts.) with true resistant arterial hypertension (RAH). Design method: 43 essential pts. were included the study. According to office ambulatory BP measurement after 2 month treatment fixed dose combination perindopril/indapamide/amlodipine 10/2.5/10 they divided into two groups: 1-st - 22 confirmed RAH 2-d 21 controlled (AH)....
Objective: Decrease of heart rate variability (HRV) (decrease SDANN < 100 ms) and left ventricular (LV) hypertrophy can be independent risk factors for future cardiovascular complications. The purpose this study was to determine relation between humoral (plasma renin activity -PRA, plasma aldosterone – pALD, 24 hour urinary metanephrines uMET), myocardial remodeling HRV in resistant hypertensive (RH) patients (pts). Design method: h Holter ECG monitoring has been recorded 20 true RH pts...
Objective to evaluate differences of left ventricular (LV) geometry and diastolic function among resistant (rHTN) controlled (HTN) hypertension patients. Design method We studied 22 patients with true rHTN confirmed by office ambulatory blood pressure monitoring (ABPM) despite the use 3 antihypertensive medications a diuretic. Ambulatory identified 21 participants triple therapy. Two groups were comparable for age, sex body mass index. All underwent examination including: biochemical...
Objective: To evaluate the relationship between parameters of carotid structure and kidney function in patients with resistance hypertension (RH). Design method: In 22 pts RH (average age 51,4 ± 2,5; 10 males) we measured ultrasonographically diameter (CD) intima-media thickness (IMT), blood flow velocities (BFV) medium cerebral arteries (MCA). All underwent full clinical laboratory screening evaluation. Kidney was estimated by glomerular filtration rate (GFR) using CKD-EPI creatinine...
Objective: To evaluate the relationship between brachial pulse pressure index (PPI) and target organs (such as brain, carotid arteries) damage in essential hypertensive patients (EH) Design method: Clinic blood (BP) was measured 136 uncomplicated pts (49,2 ± 0,94 years; 85 males) with EH. Pulse calculated ((systolic BP - diastolic BP)/ systolic BP). Cerebrovascular evaluated by studying presence or absence of cerebral white matter lesions (WML), assessed magnetic resonance imaging...
Objective: to evaluate different effects on blood pressure (BP) control depending the time of administration antihypertensive treatment in resistant (rHTN) and controlled (HTN) hypertension patients. Design method: We studied 51 patients with true rHTN confirmed by office ambulatory BP monitoring (ABPM) despite use 3 medications diuretic 58 participants HTN triple therapy. Two groups were comparable for age, sex body mass index. All at baseline randomized ingest fixed-dose triple-combination...
Objective: Improving an efficiency of resistant hypertension treatment with fixed dose combination 3-components antihypertensive medicationDesign and method: 180pts the preliminary diagnosis RAH,which was confirmed by24-h ambulatory blood pressure monitoring(ABPM),were included in study. All pts received average of4.1 ± 0.3 drugs, mainly free combinations. After ABPM were started 3-component (FDC) drugs:the FDC perindopril10 mg/indapamide2.5 mg/amlodipine10mg(108pts)or valsartan320...
Objectives: To evaluate clinical characteristics which related with true resistant arterial hypertension (rHTN). Methods: True rHTN in 78 pts was confirmed by the office and ambulatory blood pressure monitoring (ABPM) despite use of 3 antihypertensive medications diuretic 102 participants controlled (HTN) triple therapy. Before starting treatment pts. were underwent ABPM, ultrasonography heart carotid arteries, laboratory tests (serum potassium, creatinine, plasma aldosterone, active renin...
Aim: To determine the peculiarities of circadian rhythm arterial pressure in patients with true resistant hypertension (RAH) and pseudo-resistant (PRAH).Material methods. 52 suspected were examined according to criteria European Society Hypertension (ESH, 2013). Antihypertensive therapy (ACE inhibitors/sartans, calcium antagonist, a diuretic) was administered 44 RAH maximum therapeutic doses. In 20 patients, combined therapy, normalization blood not achieved. The presence confirmed it. These...
Objective: To investigate relationship between cardiovascular risk factors and left ventricular diastolic function in hypertensive chronic kidney disease (CKD) patients. Design method: We examined 94 untreated non-diabetic essential patients with II III stage of hypertensiv CKD. Echocardiography ambulatory blood pressure (BP) monitoring was performed for all patients.Glomerular filtration rate (GFR) assessment based on 24-hour endogenous creatinine clearance. Total cholesterol, high, low...
Objective: To determine possible causes of resistance to antihypertensive therapy. Design and method: The study included 101 patients with resistant hypertension (RH) (1-st gr.). In 129 after administration a standardized 3-component therapy RH was excluded (2-nd gr. pseudoRH). Plasma aldosterone, renin activity (PRA) 24-h urinary excretion rates metanephrines were estimated. C-reactive protein (hs-CRP) evaluated by immunoassay. Glomerular filtration rate (GFR) assessment based on endogenous...
Objective: To study the activity of low-grade inflammation and determine an interaction its parameters with hypertensive kidney damage in patients (pts) resistant arterial hypertension (AH). Design method: A cohort 109 pts AH (including 72 controlled 57 AH) has been studied. All addition to routine general clinical examination underwent 24-hours’ blood pressure monitoring; evaluation concentrations systemic markers (C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor alpha...