A5072226556- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- RNA and protein synthesis mechanisms
- Molecular Junctions and Nanostructures
- Luminescence and Fluorescent Materials
- Retinal Diseases and Treatments
- Carbon and Quantum Dots Applications
- Biosensors and Analytical Detection
- Nanoparticles: synthesis and applications
- Biochemical Analysis and Sensing Techniques
- Data Mining Algorithms and Applications
- Electrochemical sensors and biosensors
- Natural Language Processing Techniques
- Rough Sets and Fuzzy Logic
- HIV Research and Treatment
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Trigeminal Neuralgia and Treatments
- Advanced Biosensing Techniques and Applications
- melanin and skin pigmentation
Shaanxi University of Science and Technology
2024
Shaanxi Normal University
2017-2023
Taizhou University
2023
State Key Laboratory of Digital Medical Engineering
2019-2022
Southeast University
2019-2022
Using the commercially available and economical 6-hydroxycoumarin (6-HC) as substrate, a dual-emission ratiometric fluorescence sensor was developed to detect tyrosinase (TYR) activity based on 3-aminophenyl boronic acid functionalized quantum dots (APBA-QDs). TYR can catalyze 6-HC, monohydroxy compound, form fluorescence-enhancing o-hydroxy 6,7-dihydroxycoumarin. Owing special covalent binding between o-hydroxyl boric groups, APBA-QDs react with 6,7-dihydroxycoumarin five-membered ring...
Adenosine triphosphate (ATP) as a primary energy source plays unique role in the regulation of all cellular events. The necessity to detect ATP requires sensitive and accurate quantitative analytical strategies. Herein, we present our study developing MoS2 nanosheet-enhanced aptasensor for fluorescence polarization-based detection. A bifunctional DNA strand was designed consist chimeric aptamers that recognize capture berberine, enhancer. In absence ATP, bound berberine will be hydrolyzed...
Nanozymes with wide applications have rapidly attracted tremendous attention from various fields in the last decade. However, research on standardization of nanozymes is still lacking. Currently, accurate evaluation and effective tracing enzyme-like activity become a common concern. This work aims to develop certified reference material (CRM) Prussian blue (PBNEs) for their peroxidase (POD)-like activity. The homogeneity stability studies demonstrated that property value POD-like consistent...
The HIV-Ι trans-activation responsive (TAR) RNA–trans-activator of transcription (Tat) protein complex is crucial for the efficient integrated human immunodeficiency virus-I genome and an established therapeutic target AIDS diagnosis treatment. Developing a sensitive strategy TAR RNA-binding ligand assay could provide antiviral leads with radically new mechanism treatment AIDS. Herein, platform was using signal amplification that combines aggregation-induced emission (AIE) metal-enhanced...
Ochratoxin A (OTA) is a toxic metabolite commonly found in various foods and feedstuffs. Accurate sensitive detection of OTA needed for food safety human health. Based on common OTA-binding aptamer (OTABA), two structure-switching OTABAs, namely OTABA4 OTABA3, were designed by configuring split G-quadruplex G-triplex, respectively, at the ends OTABA to construct aptasensors OTA. The OTABA, G-quadruplex, G-triplex all can capture thioflavin T (ThT) probe, thereby enhancing fluorescence...
Fluorescence methods are important tools to identify RNA-binding small molecules and further employed study RNA–protein interactions. Most reported fluorescence strategies based on covalent labeling of ligand or RNA, which can impede the binding between them some extent, light-off fluorescent indicator displacement methods, ask for particular indicators. Herein, a label-free strategy light-on aggregation-induced emission (AIE) feature tetraphenylethene (TPE) derivative screen is presented....