A5030834029- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Algal biology and biofuel production
- Circadian rhythm and melatonin
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Light effects on plants
- Advanced Proteomics Techniques and Applications
- Protist diversity and phylogeny
- Photoreceptor and optogenetics research
- Plant Stress Responses and Tolerance
- Metabolomics and Mass Spectrometry Studies
- Cell Image Analysis Techniques
- Adversarial Robustness in Machine Learning
- Genomics and Phylogenetic Studies
- Explainable Artificial Intelligence (XAI)
- Plant Gene Expression Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Cognitive Science and Mapping
- Anomaly Detection Techniques and Applications
- Advanced Neural Network Applications
- Bayesian Modeling and Causal Inference
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Gaze Tracking and Assistive Technology
Washington University in St. Louis
2008-2024
General Motors (United States)
2023-2024
General Motors (Poland)
2021
Texas Tech University
2008-2009
Saint Louis University
2008-2009
University of Washington
2009
Unicellular cyanobacteria have recently been recognized for their contributions to nitrogen fixation in marine environments, a function previously thought be filled mainly by filamentous such as Trichodesmium . To begin systems level analysis of the physiology unicellular N 2 -fixing microbes, we sequenced completion genome Cyanothece sp. ATCC 51142, first organism. 51142 performs oxygenic photosynthesis and fixation, separating these two incompatible processes temporally within same cell,...
Cyanobacteria, the only prokaryotes capable of oxygenic photosynthesis, are present in diverse ecological niches and play crucial roles global carbon nitrogen cycles. To proliferate nature, cyanobacteria utilize a host stress responses to accommodate periodic changes environmental conditions. A detailed knowledge composition of, as well dynamic in, proteome is necessary gain fundamental insights into such responses. Toward this goal, we have performed large-scale proteomic analysis widely...
Abstract Sensors and regulatory circuits that maintain redox homeostasis play a central role in adjusting plant metabolism development to changing environmental conditions. We report here control networks Arabidopsis (Arabidopsis thaliana) respond photosynthetic stress. independently subjected leaves two commonly used photosystem II inhibitors: high light (HL) 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU). Microarray analysis of expression patterns during the period adjustment these...
ABSTRACT The genus Cyanothece comprises unicellular cyanobacteria that are morphologically diverse and ecologically versatile. Studies over the last decade have established members of this to be important components marine ecosystem, contributing significantly nitrogen carbon cycle. System-level studies sp. ATCC 51142, a prototypic member group, revealed many interesting metabolic attributes. To identify traits define class cyanobacteria, five additional strains were sequenced completion....
Abstract Light drives the production of chemical energy and reducing equivalents in photosynthetic organisms required for assimilation essential nutrients. This process also generates strong oxidants reductants that can be damaging to cellular processes, especially during absorption excess excitation energy. Cyanobacteria, like other oxygenic organisms, respond increases energy, such as exposure cells high light (HL) by reduction antenna size photosystem content. However, mechanism how...
Photosynthetic organisms experience changes in light quantity and quality their natural habitat. In response to quality, these redistribute excitation energy adjust photosystem stoichiometry maximize the utilization of available energy. However, other cellular processes is mostly unknown. Here, we report a systematic investigation into adaptation Synechocystis species PCC 6803 that preferentially excites either II or I. We find preferential I induces massive reprogramming transcriptome. The...
Abstract Background Cyanobacteria are the only known prokaryotes capable of oxygenic photosynthesis. They play significant roles in global biogeochemical cycles and carbon sequestration, have recently been recognized as potential vehicles for production renewable biofuels. Synechocystis sp. PCC 6803 has extensively used a model organism cyanobacterial studies. DNA microarray studies shown varying degrees transcriptome reprogramming under altered environmental conditions. However, it is not...
Cyanothece sp. ATCC 51142 is a diazotrophic cyanobacterium notable for its ability to perform oxygenic photosynthesis and dinitrogen fixation in the same single cell. Previous transcriptional analysis revealed that existence of these incompatible cellular processes largely depends on tightly synchronized expression programs involving ∼30% genes genome. To expand upon current knowledge, we have utilized sensitive proteomic approaches examine impact diurnal rhythms protein complement 51142. We...
In order to accommodate the physiologically incompatible processes of photosynthesis and nitrogen fixation within same cell, unicellular nitrogen-fixing cyanobacteria have maintain a dynamic metabolic profile in light as well dark phase diel cycle. The transition from photosynthetic is marked by onset various biochemical regulatory responses, which prime intracellular environment for nitrogenase activity. Cellular respiration plays an important role during this transition, quenching oxygen...
The discovery of nitrogen fixation in unicellular cyanobacteria provided the first clues for existence a circadian clock prokaryotes. However, recalcitrance to genetic manipulation barred their use as model systems deciphering function. Here, we explore now genetically amenable Cyanothece 51142, unicellular, nitrogen-fixing cyanobacterium. Unlike non-diazotrophic models, 51142 exhibits conspicuous self-sustained rhythms various discernable phenotypes, offering platform directly study effects...
Life on earth is strongly affected by alternating day and night cycles. Accordingly, many organisms have evolved an internal timekeeping system with a period of approximately 24 hours. Cyanobacteria are the only known prokaryotes robust rhythms under control central clock. Numerous studies been conducted to elucidate components circadian clock identify circadian-controlled genes. However, complex interactions between endogenous external cues currently not well understood, direct mathematical...
Cyanobacteria are oxygenic photoautotrophs notable for their ability to utilize atmospheric CO2 as the major source of carbon. The prospect using cyanobacteria convert solar energy and high concentrations efficiently into biomass renewable sources has sparked substantial interest in flue gas from coal-burning power plants a inorganic However, order guide further advances this area, better understanding metabolic changes that occur under conditions is needed. To determine effect on cell...
Life on earth is strongly regulated by the day-night cycle, widely known as diurnal cycle. Accordingly, many organisms have developed an internal time keeping mechanism; circadian clock, in order to maintain these rhythms even with short term modification of external light patterns. In previous studies, different biological processes been identified either or controlled. understand interactions between and effect input individual rhythms, it important develop a mathematical model which can...
Living cells are complex dynamic systems, showing a remarkable ability to adapt different environmental conditions for their survival. Central this characteristic trait is an underlying regulatory mechanism that controls various biological processes. Unraveling the basic principles of cellular regulation fundamental challenge and main subject article. In medical sciences, understanding can lead new treatments diseases, such as cancer diabetes, while facilitating drug discovery. agriculture,...
Bayesian networks have extensively been used in numerous fields including artificial intelligence, decision theory and control. Its ability to utilize noisy missing data makes it a good candidate study biological systems. In this paper we propose the use of network approach cellular response cyanobacteria. We discuss how combine individual gene expressions, obtained from microarrays generated using different platforms, get process level behaviors. Biological processes carry more information...
Life on earth is strongly affected by the day-night cycle, also known as diurnal cycle. Due to its importance in survival, many organisms have developed an internal time keeping mechanism that goes name of circadian rhythm. Light plays a vital role for photosynthetic cyanobacteria and changes light pattern result adaptive underlying biological processes at cellular level. Processes under control are able maintain their rhythm even it important isolate these from those whose rhythms light. As...
A significant obstacle to achieving autonomous driving (AD) and advanced driver-assistance systems (ADAS) functionality in passenger vehicles is high-fidelity perception at a sufficiently low cost of computation sensors. An area research that aims address this challenge takes inspiration from human foveal vision by using attention-based sensing. This work presents an end-to-end computer vision-based Deep Q-Network (DQN) technique intelligently selects priority region image place greater...