A5089479281- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Microbial Community Ecology and Physiology
- Endometriosis Research and Treatment
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Biocrusts and Microbial Ecology
- Synthesis and biological activity
- Ear Surgery and Otitis Media
- Estrogen and related hormone effects
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Antimicrobial Peptides and Activities
- Hippo pathway signaling and YAP/TAZ
- Sinusitis and nasal conditions
- Photoreceptor and optogenetics research
- Immune Response and Inflammation
- Uterine Myomas and Treatments
- Proteoglycans and glycosaminoglycans research
- NF-κB Signaling Pathways
- Bioactive Compounds and Antitumor Agents
- Plant Stress Responses and Tolerance
All India Institute of Medical Sciences
2010-2025
Washington University in St. Louis
2009-2025
All India Institute of Medical Sciences Raipur
2025
All India Institute of Medical Sciences Bhopal
2025
Post Graduate Institute of Medical Education and Research
2025
Central University of Tamil Nadu
2025
King George's Medical University
2022
Institute of Medical Sciences
2020
Central University of Jharkhand
2016-2018
Indian Institute of Technology BHU
2018
We utilized a full genome cDNA microarray to identify the genes that comprise peroxide stimulon in cyanobacterium Synechocystis sp. strain PCC 6803. determined gene (slr1738) encoding protein similar PerR Bacillus subtilis was induced by peroxide. constructed knockout and used it help components of regulon, we found regulatory properties were consistent with hypothesis functions as repressor. This effort guided finding putative boxes positions upstream specific careful statistical analysis....
Sirtuin (SIRT) pathway has a crucial role in Alzheimer’s disease (AD). The present study evaluated the alterations serum sirtuin1 (SIRT1) concentration healthy individuals (young and old) patients with AD mild cognitive impairment (MCI). Blood samples were collected from 40 9 MCI as cases 22 young adults elderly controls. Serum SIRT1 was estimated by Surface Plasmon Resonance (SPR), Western Blot Enzyme Linked Immunosorbent Assay (ELISA). A significant (p<0.0001) decline observed (2.27±0.46...
Tracheostomy is a common surgical procedure, and increasingly performed in the intensive care unit (ICU) as opposed to operating room. Procedural knowledge essential therefore outlined this review. We also review several high-quality studies comparing percutaneous dilational tracheostomy open tracheostomy. The method has comparable, if not superior, safety profile lower cost compared with approach; chosen. Standard specialized varieties of tubes are available appropriate type determined by...
Abstract A full-genome microarray of the (oxy)photosynthetic cyanobacterium Synechocystis sp. PCC 6803 was used to identify genes that were transcriptionally regulated by growth in iron (Fe)-deficient versus Fe-sufficient media. Transcript accumulation for 3,165 genome analyzed using an analysis variance model accounted slide and replicate (random) effects dye (a fixed) effect testing differences four time periods. We determined 85 showed statistically significant changes level transcription...
Cyanobacteria, the only prokaryotes capable of oxygenic photosynthesis, are present in diverse ecological niches and play crucial roles global carbon nitrogen cycles. To proliferate nature, cyanobacteria utilize a host stress responses to accommodate periodic changes environmental conditions. A detailed knowledge composition of, as well dynamic in, proteome is necessary gain fundamental insights into such responses. Toward this goal, we have performed large-scale proteomic analysis widely...
Abstract Light drives the production of chemical energy and reducing equivalents in photosynthetic organisms required for assimilation essential nutrients. This process also generates strong oxidants reductants that can be damaging to cellular processes, especially during absorption excess excitation energy. Cyanobacteria, like other oxygenic organisms, respond increases energy, such as exposure cells high light (HL) by reduction antenna size photosystem content. However, mechanism how...
Photosynthetic organisms experience changes in light quantity and quality their natural habitat. In response to quality, these redistribute excitation energy adjust photosystem stoichiometry maximize the utilization of available energy. However, other cellular processes is mostly unknown. Here, we report a systematic investigation into adaptation Synechocystis species PCC 6803 that preferentially excites either II or I. We find preferential I induces massive reprogramming transcriptome. The...
Abstract Background Cyanobacteria are the only known prokaryotes capable of oxygenic photosynthesis. They play significant roles in global biogeochemical cycles and carbon sequestration, have recently been recognized as potential vehicles for production renewable biofuels. Synechocystis sp. PCC 6803 has extensively used a model organism cyanobacterial studies. DNA microarray studies shown varying degrees transcriptome reprogramming under altered environmental conditions. However, it is not...
Expression profiles of Synechocystis sp. PCC 6803 genes in response to growth iron-deficient versus iron-sufficient media and after 30 min treatment with H(2)O(2) were determined using a full-genome microarray. We used an anova model that accounted for slide replicate (random) effects as well dye (a fixed) identify statistically significant, differentially expressed changed by 1.25-fold or greater during each these experiments. utilized this microarray data gene clusters regulated under...
The deletion of a gene coding for histidine kinase (sll0750, Hik8) in the unicellular cyanobacterium Synechocystis sp. strain PCC 6803 resulted conditional lethal phenotype with pleiotropic effect on expression genes involved glucose metabolism. This mutant had comparable doubling times to wild type (WT) continuous-light-grown photoautotrophic and mixotrophic cultures, whereas it grew poorly under conditions different light dark cycles. Growth was completely stopped, cells eventually died,...
The evolution of oxygenic photosynthesis in cyanobacteria nearly three billion years ago provided abundant reducing power and facilitated the elaboration numerous oxygen-dependent reactions our biosphere. Cyanobacteria contain an internal thylakoid membrane system, site photosynthesis, a typical Gram-negative envelope system. Like other organisms, extracytoplasmic space houses cysteine-containing proteins. However, existence biochemical system for disulfide bond formation remains to be...
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and glycogen synthase kinase (GSK3) are novel tumor suppressors, emerging evidence has suggested their active role in oral cancer pathogenesis. In the present study, 112 human samples, including 55 fresh samples of 14 adjacent normal tissues, 25 noninvasive tumors, 18 invasive were included. messenger RNA (mRNA) expression, promoter methylation RECK gene, as well expression GSK3β, phospho/total β-catenin, c-myc, measured...
A mutant (Δ5) of Synechocystis sp. strain PCC 6803 constructed by inactivating five inorganic carbon sequestration systems did not take up CO2 or HCO3− and was unable to grow in air with without glucose. The Δ4 which BicA is the only active system showed low activity uptake grew under these conditions but more slowly than wild-type strain. Δ5 required 1.7% attain half maximal growth rate. Electron transport mutants strongly inhibited high light intensities, susceptible mutant. results...