A5068846038- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Genetics and Reproduction
- Sexual Differentiation and Disorders
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Digestive system and related health
- Global Peace and Security Dynamics
- Gut microbiota and health
- Cancer-related gene regulation
Bar-Ilan University
2021-2024
Hebrew University of Jerusalem
2020-2023
Abstract TET2/3 play a well-known role in epigenetic regulation and mouse development. However, their function cellular differentiation tissue homeostasis remains poorly understood. Here we show that ablation of intestinal epithelial cells results murine phenotype characterized by severe imbalance the small intestine. Tet2/3 -deleted mice pronounced loss mature Paneth as well fewer Tuft more Enteroendocrine cells. Further major changes DNA methylation at putative enhancers, which are...
Male development in mammals depends on the activity of two SOX gene: Sry and Sox9, embryonic testis. As deletion Enhancer 13 (Enh13) Sox9 gene results XY male-to-female sex reversal, we explored critical elements necessary for its function hence, testis male development. Here, demonstrate that while microdeletions individual transcription factor binding sites (TFBS) Enh13 lead to normal testicular development, combined just SRY/SOX motifs can alone fully abolish leading reversal. This...
Abstract Gonadal sex determination relies on tipping a delicate balance involving the activation and repression of several transcription factors signalling pathways. This is likely mediated by numerous non-coding regulatory elements that shape sex-specific transcriptomic programs. To explore dynamics these in detail, we performed paired time-series chromatin accessibility assays pre-granulosa Sertoli cells throughout their development embryo, making use new existing mouse reporter lines....
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