A5063035222- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- DNA and Nucleic Acid Chemistry
- Advanced Synthetic Organic Chemistry
- Glycosylation and Glycoproteins Research
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
Savitribai Phule Pune University
2010-2013
Abasaheb Garware College
2012
New bicyclic conidine iminosugars 1d and 1e were synthesized from D-glucose. Thus, D-glucose was converted to sugar β-amino acids 3a 3b in good yields. Individual treatment of 3a/3b with the Mukaiyama reagent afforded β-lactams 4a/4b that on reduction LiAlH4/AlCl3 gave azetidines 5a/5b a appendage. Reductive aminocyclization corresponding 1d/1e. Based 1H NMR DFT calculation studies conformation assigned as half chair A2 boat B2. The glycosidase inhibitory activities such α-mannosidase,...
Abstract A highly stereoselective route to densely functionalized cyclohexanes is described, via a Cinchona ‐based bifunctional organocatalyzed Henry/Michael/retro‐Henry/Henry domino reaction. The peculiar stereoconvergent mechanism allows the creation of up four contiguous stereocenters in stereodefined manner starting from both achiral aldehydes and racemic nitro alcohols. simple efficient protocol can be exploited synthesize wide range substrates also useful bioactive molecules.
Abstract The synthesis of a new, highly efficient cis ‐ion‐tagged catalyst ( 8a ), possessing an amide linkage between the imidazolium tag and proline ring, is described. This new bench‐stable has been tested in classic asymmetric aldol condensation ketones aldehydes “in presence” water, proposed as valuable alternative to analogous but more sensitive ester cis‐ 2d . Catalyst displayed excellent efficiency terms loading stereochemical control.
A new oxyacetamide-modified dinucleoside with 5′-(<i>S</i>) chirality, a hydrophobic 5′-<i>C</i>-(2-methoxyethyl) group, and 2′-<i>O</i>-methyl group was synthesized from <sc>d</sc>-glucose. This showed helical structure based on CD NMR spectroscopy. The sugar puckering at the 5′ 3′ ends were found to be ‘<i>S</i>’- ‘<i>N</i>’-types, respectively. These results substantiated by ab initio density functional theory.