A5085151831- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Computational Drug Discovery Methods
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Synthesis and biological activity
- Lung Cancer Treatments and Mutations
- Lipid Membrane Structure and Behavior
- interferon and immune responses
- HIV Research and Treatment
- MicroRNA in disease regulation
- Evolution and Genetic Dynamics
- Monoclonal and Polyclonal Antibodies Research
National Centre for Cell Science
2016-2025
Savitribai Phule Pune University
2010-2024
National Institute of Pharmaceutical Education and Research
2021
Institute of Bioinformatics
2010
Indian Institute of Technology Delhi
2005-2008
National Institute of Immunology
2003
IL-6 and IL-17 are paradoxical cytokines that progress inflammatory states in chronic diseases, including cancer. In lung cancer, their role has been elucidated to favor cancer development by modulating signaling mechanisms critical cellular growth. The intrinsic ability of these influence macroautophagy is yet another reason facilitate Here, we employed a systems immunology approach discover the mechanistic development. biological system, at later stages, activation NFkB stimulates...
Access to the complete human genome sequence as well sequences of pathogenic organisms provides information that can result in an avalanche therapeutic targets.Structure-based design is one first techniques be used drug design.Structure based refers specifically finding and complementing 3D structure (binding and/or active site) a target molecule such receptor protein.The aim this review give outline studies field has helped discovery process new drugs.The emphasis will on...
New bicyclic conidine iminosugars 1d and 1e were synthesized from D-glucose. Thus, D-glucose was converted to sugar β-amino acids 3a 3b in good yields. Individual treatment of 3a/3b with the Mukaiyama reagent afforded β-lactams 4a/4b that on reduction LiAlH4/AlCl3 gave azetidines 5a/5b a appendage. Reductive aminocyclization corresponding 1d/1e. Based 1H NMR DFT calculation studies conformation assigned as half chair A2 boat B2. The glycosidase inhibitory activities such α-mannosidase,...
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due lack appropriate medication and the growing problem drug resistance. Natural compounds such as coumarins serve complementary therapeutic agents in addition current treatment modalities. In study, we have performed an in-silico screening coumarin derivatives their anti-leishmanial properties has been explored both in-vitro in-vivo. One (compound 2) exhibited leishmanicidal...
Non-small cell lung cancer (NSCLC) is the most common type of cancer. According to 2020 reports, globally, 2.2 million cases are reported every year, with mortality number being as high 1.8 patients. To study NSCLC, systems biology offers mathematical modeling a tool understand complex pathways and provide insights into identification biomarkers potential therapeutic targets, which aids precision therapy. Mathematical modeling, specifically ordinary differential equations (ODEs), used better...
Abstract Conserved telomere maintenance component 1 (CTC1) is an important of the CST (CTC1-STN1-TEN1) complex, involved in maintaining stability telomeric DNA. Several non-synonymous single-nucleotide polymorphisms (nsSNPs) CTC1 have been reported to cause Coats plus syndrome and Dyskeratosis congenital diseases. Here, we performed sequence structure analyses nsSNPs using state-of-the-art computational methods. The structure-based study focuses on C-terminal OB-fold region CTC1. There are...
IL12 and IL10 are two of the major cytokines which control fate Leishmaniasis. This paper presents models healthy state diseased shows how secretion is responsible for parasite elimination can jeopardize promote its survival. Epigenetic modification in host promoter decide parasites. It was observed that reciprocal relationship exists between majorly controlled by a transcription factor NFAT5 from Rel family factors. By targeting this at cellular level, it might be possible to modulate...
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the Leishmania genus. Despite efforts to control and treat disease, it still remains major public health problem in many countries. Synthetic biology rapidly evolving interdisciplinary field that combines biology, engineering, computer science design construct novel biological systems. In recent years, synthetic approaches have shown great promise for developing new effective strategies combat leishmaniasis. this...
The hallmark characteristic of macrophages lies in their inherent plasticity, allowing them to adapt dynamic microenvironments. Leishmania strategically modulates the phenotypic plasticity macrophages, creating a favorable environment for intracellular survival and persistent infection through regulatory cytokine such as interleukin (IL)-10. Nevertheless, these effector cells can counteract by modulating crucial cytokines like IL-12 key components involved its production. Using sophisticated...
Abstract Leishmania major is a parasite that resides and replicates in macrophages. We previously showed the enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK to proleishmanial effects. As Raf PI3K have Ras-binding domain exert opposite effects on infection, we examined whether Ras isoforms had differential roles infection. observed L. N-Ras H-Ras expression K-Ras infection activity activity. TLR2 short hairpin RNA or anti-TLR2 anti-lipophosphoglycan Abs reversed...
Antibiotic resistance against
With the Entamoeba genome essentially complete, organism can be studied from a whole standpoint.The understanding of cellular mechanisms and interactions between components is instrumental to development new effective drugs vaccines.Metabolic pathway analysis becoming increasingly important for assessing inherent network properties in reconstructed biochemical reaction networks.Metabolic pathways illustrate how proteins work concert produce compounds or transmit information at different...
Journal Article Biological network modeling identifies IPCS in Leishmania as a therapeutic target Get access Vineetha Mandlik, Mandlik National Centre for Cell Science, NCCS Complex, Pune University Campus, Ganeshkhind, 411007, India. Fax: +91-20-25692259, +91-20-25708296 Search other works by this author on: Oxford Academic Google Scholar Sonali Shinde, Shinde Ashish Chaudhary, Chaudhary Department of Applied Microbiology, Faculty Banaras Hindu University, Varanasi 221005, India Shailza...
In many regions of the world, Leishmaniasis is a cause substantial mortality and ailment. Due to impediment in available treatment, development novel effective treatments indispensable. Significance autophagy has been accentuated infectious disease as well Leishmaniasis, it having capability be manifested therapeutic target. By evincing regime, this study emphasized on critical role ATG4.1-ATG8 ATG5-ATG12 complexes Leishmania species. The objective here was identify ATG8 potential target...